CACTIN and HMGB2

Number of citations of the paper that reports this interaction (PubMedID 29721183)
2

Data Source:
BioGRID (two hybrid)

		CACTIN	HMGB2
Description		cactin, spliceosome C complex subunit	high mobility group box 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Nuclear Speck Catalytic Step 2 Spliceosome	Nuclear Chromatin Condensed Chromosome Extracellular Space Cell Nucleus Nucleoplasm Nucleolus Cytoplasm Protein-containing Complex Perinuclear Region Of Cytoplasm
	Molecular Function	RNA Binding Protein Binding	Four-way Junction DNA Binding Proximal Promoter Sequence-specific DNA Binding DNA Binding Damaged DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Transcription Coactivator Activity RNA Binding Protein Binding Transcription Factor Binding Drug Binding DNA Binding, Bending Protein Domain Specific Binding Chemoattractant Activity Transcription Regulatory Region DNA Binding Non-sequence-specific DNA Binding, Bending RAGE Receptor Binding Supercoiled DNA Binding
	Biological Process	MRNA Splicing, Via Spliceosome Negative Regulation Of Protein Phosphorylation Multicellular Organism Development Negative Regulation Of Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Interferon-beta Production Negative Regulation Of Interleukin-8 Production Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Toll-like Receptor Signaling Pathway Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Negative Regulation Of Type I Interferon-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor	Positive Regulation Of Endothelial Cell Proliferation Inflammatory Response To Antigenic Stimulus DNA Topological Change Apoptotic DNA Fragmentation DNA Recombination Chromatin Organization Nucleosome Assembly Chromatin Remodeling Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Spermatid Nucleus Differentiation Male Gonad Development Positive Regulation Of Nuclease Activity DNA Geometric Change Response To Lipopolysaccharide Positive Regulation Of Interferon-beta Production V(D)J Recombination Response To Drug Positive Regulation Of DNA Binding Innate Immune Response Positive Regulation Of Innate Immune Response Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Megakaryocyte Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Response To Steroid Hormone Regulation Of Neurogenesis Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Positive Chemotaxis DNA Ligation Involved In DNA Repair Cell Chemotaxis Cellular Response To Lipopolysaccharide Regulation Of Stem Cell Proliferation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Pathways			Apoptosis induced DNA fragmentation
Drugs
Diseases
GWAS
Interacting Genes		3 interacting genes: HMGB2 NELFE TRIM39	37 interacting genes: APEX1 APP AR ARCN1 C1QBP CACTIN CHAF1A CREBBP CSNK1A1 EIF1 FBXO7 GZMA GZMK H3-3A HACD3 HDLBP HMGA1 LZTS1 MIEN1 NAP1L1 NCBP3 NEXN NR3C1 PGR PKNOX1 POU2F1 POU2F2 POU3F1 POU5F1 PRKDC RAG1 SAMM50 SET TP53 ZNF428 ZNF622 ZNF668
Entrez ID		58509	3148
HPRD ID		18930	01229
Ensembl ID		ENSG00000105298	ENSG00000164104
Uniprot IDs		Q8WUQ7	P26583
PDB IDs		6QDV
Enriched GO Terms of Interacting Partners?
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