ABCD3 and ABCD1

Number of citations of the paper that reports this interaction (PubMedID 22939629)
262

Data Source:
BioGRID (two hybrid, biochemical)
HPRD (in vivo, two hybrid)

		ABCD3	ABCD1
Description		ATP binding cassette subfamily D member 3	ATP binding cassette subfamily D member 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Mitochondrion Peroxisome Peroxisomal Membrane Peroxisomal Matrix Cytosol Membrane Integral Component Of Membrane Intracellular Membrane-bounded Organelle	Cytoplasm Lysosomal Membrane Peroxisome Peroxisomal Membrane Integral Component Of Peroxisomal Membrane Endoplasmic Reticulum Membrane Cytosol Membrane Mitochondrial Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Long-chain Fatty Acid Transporter Activity Protein Binding ATP Binding ATPase Activity ATPase Activity, Coupled To Transmembrane Movement Of Substances Protein Homodimerization Activity Protein Self-association	Long-chain Fatty Acid Transporter Activity Protein Binding ATP Binding Fatty-acyl-CoA Transmembrane Transporter Activity ATPase Activity Enzyme Binding ATPase Activity, Coupled To Transmembrane Movement Of Substances Identical Protein Binding Protein Homodimerization Activity ADP Binding
	Biological Process	Fatty Acid Biosynthetic Process Fatty Acid Beta-oxidation Peroxisome Organization Response To Organic Cyclic Compound Peroxisomal Long-chain Fatty Acid Import Response To Drug Very Long-chain Fatty Acid Catabolic Process Transmembrane Transport	Regulation Of Oxidative Phosphorylation Fatty Acid Beta-oxidation Peroxisome Organization Peroxisomal Long-chain Fatty Acid Import Fatty-acyl-CoA Transport Peroxisomal Membrane Transport Fatty Acid Elongation Regulation Of Fatty Acid Beta-oxidation Positive Regulation Of Fatty Acid Beta-oxidation Fatty Acid Beta-oxidation Using Acyl-CoA Oxidase Alpha-linolenic Acid Metabolic Process Very Long-chain Fatty-acyl-CoA Catabolic Process Long-chain Fatty Acid Catabolic Process Very Long-chain Fatty Acid Catabolic Process Myelin Maintenance Linoleic Acid Metabolic Process Regulation Of Mitochondrial Depolarization Transmembrane Transport Fatty Acid Homeostasis Sterol Homeostasis Negative Regulation Of Cytokine Production Involved In Inflammatory Response Regulation Of Cellular Response To Oxidative Stress Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Neuron Projection Maintenance Positive Regulation Of Unsaturated Fatty Acid Biosynthetic Process
Pathways		ABC transporters in lipid homeostasis Class I peroxisomal membrane protein import	ABC transporters in lipid homeostasis Linoleic acid (LA) metabolism alpha-linolenic acid (ALA) metabolism Beta-oxidation of very long chain fatty acids Defective ABCD1 causes adrenoleukodystrophy (ALD) Class I peroxisomal membrane protein import
Drugs
Diseases			Adrenoleukodystrophy (ALD), including: Schilder-Addison Complex; Childhood cerebral adrenoleukodystrophy (CCER); adrenomyeloneuropathy (AMN)
GWAS
Interacting Genes		7 interacting genes: ABCD1 ABCD2 ACADM COL6A2 PEX19 PSMA1 TUFT1	6 interacting genes: ABCD2 ABCD3 ATP6AP1 PEX19 RPSA SLC27A2
Entrez ID		5825	215
HPRD ID		01368	02300
Ensembl ID		ENSG00000117528	ENSG00000101986
Uniprot IDs		P28288	P33897
PDB IDs
Enriched GO Terms of Interacting Partners?
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