PTPRS and PTPRA

Number of citations of the paper that reports this interaction (PubMedID 10777529)
16

Data Source:
HPRD (in vitro, in vivo)

		PTPRS	PTPRA
Description		protein tyrosine phosphatase receptor type S	protein tyrosine phosphatase receptor type A
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane Integral Component Of Plasma Membrane Cell Junction Integral Component Of Synaptic Vesicle Membrane Axon Growth Cone Perikaryon Extracellular Exosome Schaffer Collateral - CA1 Synapse Glutamatergic Synapse Integral Component Of Presynaptic Membrane Integral Component Of Postsynaptic Density Membrane	Plasma Membrane Integral Component Of Plasma Membrane Receptor Complex Extracellular Exosome Schaffer Collateral - CA1 Synapse Integral Component Of Synaptic Membrane
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Heparin Binding Chondroitin Sulfate Binding Heparan Sulfate Proteoglycan Binding	Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Protein Binding
	Biological Process	Protein Dephosphorylation Negative Regulation Of Neuron Projection Development Spinal Cord Development Cerebellum Development Hippocampus Development Cerebral Cortex Development Corpus Callosum Development Negative Regulation Of Axon Extension Negative Regulation Of Interferon-alpha Production Negative Regulation Of Interferon-beta Production Negative Regulation Of Toll-like Receptor 9 Signaling Pathway Peptidyl-tyrosine Dephosphorylation Negative Regulation Of Collateral Sprouting Negative Regulation Of Axon Regeneration Modulation Of Chemical Synaptic Transmission Negative Regulation Of Dendritic Spine Development Establishment Of Endothelial Intestinal Barrier Regulation Of Postsynaptic Density Assembly Synaptic Membrane Adhesion	MAPK Cascade Protein Dephosphorylation Axon Guidance Insulin Receptor Signaling Pathway Peptidyl-tyrosine Dephosphorylation Modulation Of Chemical Synaptic Transmission
Pathways		ECM proteoglycans Receptor-type tyrosine-protein phosphatases Synaptic adhesion-like molecules Signaling by NTRK3 (TRKC)	NCAM signaling for neurite out-growth NCAM signaling for neurite out-growth RAF/MAP kinase cascade
Drugs		Alendronic acid Etidronic acid
Diseases
GWAS		Type 2 diabetes ( 30297969) Waist-hip ratio ( 28552196)	Hip circumference adjusted for BMI ( 28552196)
Interacting Genes		26 interacting genes: CEP126 CHD3 EEF1G EGFR FEZ1 GPC2 GPC3 GPC6 KAT5 MOB4 PFN2 PPFIA1 PPFIA2 PPFIA3 PTN PTPRA PTPRD PTPRE PTPRM PTPRN RAB35 SETDB1 TUBB2A UBR1 UNC119 UTP14A	17 interacting genes: BCAR1 CALM1 EGFR FYN GABARAPL2 GRB2 HSPB1 KCNA2 LINC00839 MBP POFUT1 PRKCD PTPRD PTPRF PTPRM PTPRS SRC
Entrez ID		5802	5786
HPRD ID		03344	01476
Ensembl ID		ENSG00000105426	ENSG00000132670
Uniprot IDs		A0A0A0MR60 Q13332 Q59FX6 Q8NHS7	P18433
PDB IDs		2FH7 2YD2 2YD3 2YD9 4BPC 4PBX
Enriched GO Terms of Interacting Partners?
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