PTPRC and SEMA4D

Number of citations of the paper that reports this interaction (PubMedID 11254687)
45

Data Source:
HPRD (in vitro, in vivo)

		PTPRC	SEMA4D
Description		protein tyrosine phosphatase receptor type C	semaphorin 4D
Image
GO Annotations	Cellular Component	Cell Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion External Side Of Plasma Membrane Cytoplasmic Side Of Plasma Membrane Cell Surface Membrane Integral Component Of Membrane Secretory Granule Membrane Bleb Membrane Raft Extracellular Exosome Membrane Microdomain	Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Signaling Receptor Binding Protein Binding Heparin Binding Protein Kinase Binding Ankyrin Binding Spectrin Binding Heparan Sulfate Proteoglycan Binding	Transmembrane Signaling Receptor Activity Signaling Receptor Binding Protein Binding Semaphorin Receptor Binding Signaling Receptor Activity Chemorepellent Activity
	Biological Process	Activation Of MAPK Activity Natural Killer Cell Differentiation Negative Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of T Cell Mediated Cytotoxicity Negative Regulation Of Cytokine-mediated Signaling Pathway Hematopoietic Progenitor Cell Differentiation Immunoglobulin Biosynthetic Process Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Negative Regulation Of Protein Kinase Activity Protein Dephosphorylation Negative Regulation Of Cell Adhesion Involved In Substrate-bound Cell Migration Leukocyte Cell-cell Adhesion Cell Surface Receptor Signaling Pathway Response To Gamma Radiation Regulation Of Gene Expression Viral Process Dephosphorylation B Cell Differentiation T Cell Differentiation Positive Regulation Of B Cell Proliferation Cellular Response To Extracellular Stimulus Negative Regulation Of Protein Autophosphorylation Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Heterotypic Cell-cell Adhesion Peptidyl-tyrosine Dephosphorylation Calcium-mediated Signaling Using Intracellular Calcium Source T Cell Proliferation B Cell Proliferation Positive Regulation Of T Cell Proliferation T Cell Activation Neutrophil Degranulation Positive Regulation Of MAPK Cascade Cell Cycle Phase Transition Plasma Membrane Raft Distribution Positive Thymic T Cell Selection Negative Thymic T Cell Selection Negative Regulation Of Interleukin-2 Biosynthetic Process Positive Regulation Of Interleukin-2 Biosynthetic Process Positive Regulation Of Gamma-delta T Cell Differentiation Positive Regulation Of Protein Kinase Activity Regulation Of JAK-STAT Cascade Positive Regulation Of Alpha-beta T Cell Proliferation Positive Regulation Of Isotype Switching To IgG Isotypes Bone Marrow Development Stem Cell Development Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Phagocytosis T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway Positive Regulation Of Antigen Receptor-mediated Signaling Pathway Release Of Sequestered Calcium Ion Into Cytosol Defense Response To Virus Regulation Of Cell Cycle Regulation Of Protein Tyrosine Kinase Activity Negative Regulation Of Protein Tyrosine Kinase Activity Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Protein Tyrosine Phosphatase Activity Negative Regulation Of Microglial Cell Activation DN2 Thymocyte Differentiation Positive Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of Hematopoietic Stem Cell Migration Positive Regulation Of Stem Cell Proliferation Positive Regulation Of Extrinsic Apoptotic Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Neural Crest Cell Migration Positive Regulation Of Protein Phosphorylation Immune Response Cell Adhesion Negative Regulation Of Cell Adhesion Regulation Of Cell Shape Negative Regulation Of Alkaline Phosphatase Activity Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Positive Regulation Of Cell Migration Regulation Of Cell Projection Organization Negative Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Ossification Involved In Bone Maturation Negative Regulation Of Osteoblast Differentiation Positive Regulation Of Collateral Sprouting Regulation Of Dendrite Morphogenesis Negative Regulation Of Axon Extension Involved In Axon Guidance Positive Regulation Of Peptidyl-tyrosine Phosphorylation Negative Regulation Of Peptidyl-tyrosine Phosphorylation Negative Chemotaxis Leukocyte Aggregation Semaphorin-plexin Signaling Pathway Semaphorin-plexin Signaling Pathway Involved In Bone Trabecula Morphogenesis Positive Regulation Of Inhibitory Synapse Assembly
Pathways		Phosphorylation of CD3 and TCR zeta chains Other semaphorin interactions Neutrophil degranulation	Sema4D mediated inhibition of cell attachment and migration Sema4D induced cell migration and growth-cone collapse Other semaphorin interactions
Drugs
Diseases		T-B+Severe combined immunodeficiencies (SCIDs), including the following eight diseases: X-linked SCID; Janus kinase-3 (Jak3) deficiency; IL-7 receptor alpha (IL7R alpha) deficiency; IL-2 receptor alpha (IL2R alpha) deficiency; CD45 deficiency; CD3 deficiency; Winged Helix Nude (WHN) deficiency; Immunodeficiency with thynoma
GWAS		Asthma ( 30929738 31619474) Asthma (adult onset) ( 30929738) Celiac disease and Rheumatoid arthritis ( 26546613) Crohn's disease ( 26192919 28067908) Inflammatory bowel disease ( 26192919) Lymphocyte counts ( 27863252) Mean corpuscular hemoglobin ( 29403010 20139978 28017375) Mean corpuscular hemoglobin concentration ( 29403010) Mean corpuscular volume ( 29403010) Medication use (adrenergics, inhalants) ( 31015401) Red blood cell count ( 29403010) Rheumatoid arthritis (ACPA-positive) ( 24532676) Sum eosinophil basophil counts ( 27863252) Systemic lupus erythematosus ( 27399966) Ulcerative colitis ( 24837172) Vitiligo ( 27723757)	Blood protein levels ( 30072576 29875488) Body mass index ( 28296344) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252)
Interacting Genes		45 interacting genes: ANP32A CD1D CD2 CD22 CD247 CD28 CD4 CD8A CSNK2A1 CSNK2A2 CXCR4 DPP4 EZR FCGR3A FYN GANAB GRB2 IFNAR1 INSR IRS1 ITGAL JAK1 JAK2 JAK3 LCK LCP2 LGALS1 LSM1 LYN MAPK1 MBL2 PAEP PPFIA1 PPFIBP2 PRKCSH PTPN6 PTPRCAP RASA1 RNF11 SEMA4D SKAP1 SRC TYK2 UHRF2 ZAP70	5 interacting genes: CD72 CRK LINC00839 PLXNB1 PTPRC
Entrez ID		5788	10507
HPRD ID		01050	03520
Ensembl ID		ENSG00000081237	ENSG00000187764
Uniprot IDs		M9MML4 P08575	Q92854
PDB IDs		1YGR 1YGU 5FMV 5FN6 5FN7	1OLZ 3OL2
Enriched GO Terms of Interacting Partners?
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