CWC22 and EIF4A3

Number of citations of the paper that reports this interaction (PubMedID 22961380)
33

Data Source:
BioGRID (pull down, x-ray crystallography, fluorescent resonance energy transfer)

		CWC22	EIF4A3
Description		CWC22 spliceosome associated protein homolog	eukaryotic translation initiation factor 4A3
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex Cytosol Nuclear Speck U2-type Precatalytic Spliceosome U2-type Catalytic Step 1 Spliceosome U2-type Catalytic Step 2 Spliceosome Catalytic Step 2 Spliceosome	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Membrane Nuclear Speck Dendrite Exon-exon Junction Complex Neuronal Cell Body U2-type Catalytic Step 1 Spliceosome Catalytic Step 2 Spliceosome Glutamatergic Synapse Postsynaptic Cytosol
	Molecular Function	RNA Binding Protein Binding	RNA Binding RNA Helicase Activity MRNA Binding Protein Binding ATP Binding Poly(A) Binding Selenocysteine Insertion Sequence Binding RNA Stem-loop Binding Ribonucleoprotein Complex Binding Translation Regulator Activity
	Biological Process	MRNA Splicing, Via Spliceosome Regulation Of MRNA Splicing, Via Spliceosome	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay MRNA Splicing, Via Spliceosome RRNA Processing RNA Export From Nucleus MRNA Export From Nucleus Associative Learning Response To Organic Cyclic Compound Negative Regulation Of Translation MRNA 3'-end Processing Exploration Behavior Positive Regulation Of Translation Embryonic Cranial Skeleton Morphogenesis Cellular Response To Selenite Ion Negative Regulation Of Excitatory Postsynaptic Potential Regulation Of Translation At Postsynapse, Modulating Synaptic Transmission Negative Regulation Of Selenocysteine Incorporation Negative Regulation Of Selenocysteine Insertion Sequence Binding Cellular Response To Brain-derived Neurotrophic Factor Stimulus
Pathways		mRNA Splicing - Major Pathway	ISG15 antiviral mechanism Transport of Mature mRNA derived from an Intron-Containing Transcript Deadenylation of mRNA mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS		Body mass index ( 28892062) Schizophrenia ( 30285260)	High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Immature fraction of reticulocytes ( 27863252) Myocardial infarction ( 26708285) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252)
Interacting Genes		2 interacting genes: EIF4A3 EXOSC8	12 interacting genes: CASC3 CCDC174 CDCA7L CWC22 ESR1 MAGOH NXF1 PDCD4 RBM8A UPF1 UPF3B YWHAQ
Entrez ID		57703	9775
HPRD ID		17220	06482
Ensembl ID		ENSG00000163510	ENSG00000141543
Uniprot IDs		Q9HCG8	A0A024R8W0 I3L3H2 P38919
PDB IDs		4C9B 5MQF 5XJC 5YZG 5Z56 5Z57 5Z58 6FF7 6ICZ 6QDV	2HXY 2HYI 2J0Q 2J0S 2J0U 2XB2 3EX7 4C9B 5MQF 5XJC 5YZG 6ICZ 6QDV
Enriched GO Terms of Interacting Partners?
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