PRR12 and FASN

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		PRR12	FASN
Description		proline rich 12	fatty acid synthase
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Postsynaptic Density Cell Junction Neuron Projection	Golgi Apparatus Cytosol Plasma Membrane Membrane Melanosome Glycogen Granule Extracellular Exosome
	Molecular Function		RNA Binding [acyl-carrier-protein] S-acetyltransferase Activity [acyl-carrier-protein] S-malonyltransferase Activity 3-oxoacyl-[acyl-carrier-protein] Synthase Activity 3-oxoacyl-[acyl-carrier-protein] Reductase (NADPH) Activity 3-hydroxypalmitoyl-[acyl-carrier-protein] Dehydratase Activity Oleoyl-[acyl-carrier-protein] Hydrolase Activity Protein Binding Drug Binding (3R)-hydroxymyristoyl-[acyl-carrier-protein] Dehydratase Activity 3-hydroxydecanoyl-[acyl-carrier-protein] Dehydratase Activity Myristoyl-[acyl-carrier-protein] Hydrolase Activity Palmitoyl-[acyl-carrier-protein] Hydrolase Activity Phosphopantetheine Binding Identical Protein Binding Cadherin Binding Enoyl-[acyl-carrier-protein] Reductase (NADPH, A-specific) Activity 3-hydroxyoctanoyl-[acyl-carrier-protein] Dehydratase Activity NADPH Binding 3-oxo-glutaryl-[acp] Methyl Ester Reductase Activity 3-oxo-pimeloyl-[acp] Methyl Ester Reductase Activity
	Biological Process		Osteoblast Differentiation Glandular Epithelial Cell Development Acetyl-CoA Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Ether Lipid Biosynthetic Process Neutrophil Differentiation Monocyte Differentiation Mammary Gland Development Positive Regulation Of Cellular Metabolic Process Regulation Of Cholesterol Biosynthetic Process Fatty-acyl-CoA Biosynthetic Process Oxidation-reduction Process Cellular Response To Interleukin-4 Establishment Of Endothelial Intestinal Barrier
Pathways			ChREBP activates metabolic gene expression Vitamin B5 (pantothenate) metabolism Activation of gene expression by SREBF (SREBP) Fatty acyl-CoA biosynthesis Fatty acyl-CoA biosynthesis NR1H2 & NR1H3 regulate gene expression linked to lipogenesis
Drugs			Cerulenin Orlistat
Diseases
GWAS		Fibrinogen levels ( 26561523) Schizophrenia ( 25056061 29483656) Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) ( 30573655)	Blood protein levels ( 30072576) Major depressive disorder ( 27777418) Malate levels ( 31560688)
Interacting Genes		2 interacting genes: FASN PUM1	7 interacting genes: AKT1 EWSR1 MTDH NDRG1 PRR12 PTEN YWHAQ
Entrez ID		57479	2194
HPRD ID		19620	02567
Ensembl ID		ENSG00000126464	ENSG00000169710
Uniprot IDs		Q9ULL5	P49327
PDB IDs			1XKT 2CG5 2JFD 2JFK 2PX6 3HHD 3TJM 4PIV 4W82 4W9N 4Z49 5C37 6NNA
Enriched GO Terms of Interacting Partners?
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