PTHLH and PTH1R

Number of citations of the paper that reports this interaction (PubMedID 9108031)
9

Data Source:
BioGRID (pull down)
HPRD (in vivo)

		PTHLH	PTH1R
Description		parathyroid hormone like hormone	parathyroid hormone 1 receptor
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleoplasm Cytoplasm Golgi Apparatus Cytosol	Cell Nucleus Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Basolateral Plasma Membrane Apical Plasma Membrane Brush Border Membrane Receptor Complex
	Molecular Function	Hormone Activity Protein Binding Peptide Hormone Receptor Binding	Parathyroid Hormone Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity Peptide Hormone Binding Protein Homodimerization Activity Protein Self-association
	Biological Process	Skeletal System Development Osteoblast Development G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Female Pregnancy Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Epidermis Development Regulation Of Gene Expression Bone Mineralization Regulation Of Chondrocyte Differentiation Negative Regulation Of Chondrocyte Differentiation CAMP Metabolic Process Negative Regulation Of Chondrocyte Development	Skeletal System Development In Utero Embryonic Development Chondrocyte Differentiation Osteoblast Development Cellular Calcium Ion Homeostasis Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Aging Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Bone Mineralization Bone Resorption Cell Maturation Positive Regulation Of Inositol Phosphate Biosynthetic Process
Pathways		Class B/2 (Secretin family receptors) G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production	Class B/2 (Secretin family receptors) G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production
Drugs			Abaloparatide Parathyroid hormone Teriparatide
Diseases			Primary failure of tooth eruption Blomstrand syndrome; Blomstrand chondrodysplasia Eiken dysplasia Metaphyseal dysplasias, including: Metaphyseal dysplasia, Schmid type; Metaphyseal dysplasia, McKusik type; Metaphyseal dysplasia, Jansen type; Shwachman-Bodian-Diamond syndrome (SBDS); Metaphyseal anadysplasia (MAD)
GWAS		Asthma and hay fever ( 24388013) Blood protein levels ( 30072576 29875488) Bone mineral density (paediatric, lower limb) ( 24945404) Bone mineral density (paediatric, total body less head) ( 24945404) Breast cancer ( 23535729 23535733 27117709 31757997) Breast cancer (estrogen-receptor negative) ( 27117709) Breast cancer (estrogen-receptor negative, progesterone-receptor negative, and human epidermal growth factor-receptor negative) ( 24325915) Breast size ( 22747683 27182965) Height ( 31562340) Lumbar spine bone mineral density (trabecular) ( 27476799) Lung function (FEV1) ( 26635082) Lung function (FVC) ( 26635082) Male-pattern baldness ( 28196072) Ossification of the posterior longitudinal ligament of the spine ( 25064007) Osteoarthritis (hip) ( 30664745)	Birth weight ( 31043758 27680694) Microalbuminuria ( 26631737) Offspring birth weight ( 31043758) Type 2 diabetes ( 30054458)
Interacting Genes		7 interacting genes: ARRB1 CDK2 IL6 KLK3 KPNB1 MTDH PTH1R	8 interacting genes: ARRB1 GNB1 PTH PTHLH SLC9A3R1 SLC9A3R2 UBC YWHAH
Entrez ID		5744	5745
HPRD ID		01348	01347
Ensembl ID		ENSG00000087494	ENSG00000160801
Uniprot IDs		A0A024RB29 P12272 Q53XY9	A1LPH3 Q03431 Q0VGD7
PDB IDs		1BZG 1ET3 1M5N 3FFD 3H3G	1BL1 1ET2 1ET3 3C4M 3H3G 3L2J 4Z8J 5EMB 6NBF 6NBH 6NBI
Enriched GO Terms of Interacting Partners?
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