PTGIR and ADCY10

Number of citations of the paper that reports this interaction (PubMedID 10446129)
18

Data Source:
HPRD (in vitro)

		PTGIR	ADCY10
Description		prostaglandin I2 receptor	adenylate cyclase 10
Image		No pdb structure
GO Annotations	Cellular Component	Cell Cytosol Plasma Membrane Integral Component Of Plasma Membrane	Extracellular Region Nucleus Cytoplasm Mitochondrion Cytosol Microtubule Cytoskeleton Apical Plasma Membrane Dendrite Growth Cone Motile Cilium Neuronal Cell Body Basal Part Of Cell Perinuclear Region Of Cytoplasm
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Prostacyclin Receptor Activity	Magnesium Ion Binding Adenylate Cyclase Activity ATP Binding Manganese Ion Binding ATPase Binding Bicarbonate Binding
	Biological Process	Inflammatory Response G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Response To Lipopolysaccharide Negative Regulation Of Smooth Muscle Cell Proliferation	Epithelial Cilium Movement CAMP Biosynthetic Process Spermatogenesis Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Cellular Response To Inorganic Substance
Pathways		Prostanoid ligand receptors Prostacyclin signalling through prostacyclin receptor Prostacyclin signalling through prostacyclin receptor G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production	Hedgehog 'off' state
Drugs		Treprostinil Iloprost Dinoprost Tromethamine Epoprostenol Beraprost Selexipag
Diseases
GWAS		Crohn's disease ( 28067908)
Interacting Genes		10 interacting genes: ADCY10 GNA11 GNAQ GNAS LNX1 PDE6D PDZD3 PRKCA RAB11A TBXA2R	2 interacting genes: PTGIR SSTR5
Entrez ID		5739	55811
HPRD ID		08959	05549
Ensembl ID		ENSG00000160013	ENSG00000143199
Uniprot IDs		P43119	A0A0K0K1J8 Q96PN6
PDB IDs			4CLF 4CLK 4CLL 4CLP 4CLS 4CLT 4CLU 4CLW 4CLY 4CLZ 4CM0 4CM2 4OYA 4OYB 4OYI 4OYM 4OYO 4OYP 4OYW 4OYX 4OYZ 4OZ2 4OZ3 4UST 4USU 4USV 4USW 5D0R 5IV3 5IV4
Enriched GO Terms of Interacting Partners?
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