BAG1 and RB1

Number of citations of the paper that reports this interaction (PubMedID 12845674)
8

Data Source:
BioGRID (affinity chromatography technology)
HPRD (two hybrid, in vitro, in vivo)

		BAG1	RB1
Description		BAG cochaperone 1	RB transcriptional corepressor 1
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Chromatin Nucleus Nucleoplasm Transcription Factor Complex Spindle Cyclin/CDK Positive Transcription Elongation Factor Complex SWI/SNF Complex PML Body Rb-E2F Complex
	Molecular Function	Adenyl-nucleotide Exchange Factor Activity Protein Binding Ubiquitin Protein Ligase Binding Chaperone Binding	Proximal Promoter Sequence-specific DNA Binding RNA Polymerase II Regulatory Region DNA Binding RNA Polymerase II Activating Transcription Factor Binding DNA Binding DNA-binding Transcription Factor Activity Transcription Coactivator Activity Protein Binding Transcription Factor Binding Kinase Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Androgen Receptor Binding Phosphoprotein Binding Importin-alpha Family Protein Binding Disordered Domain Specific Binding
	Biological Process	Apoptotic Process Cell Surface Receptor Signaling Pathway Negative Regulation Of Apoptotic Process Regulation Of Catalytic Activity Chaperone Cofactor-dependent Protein Refolding Regulation Of Cellular Response To Heat	G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II Tissue Homeostasis Aortic Valve Morphogenesis Chromatin Remodeling Regulation Of Transcription, DNA-templated Negative Regulation Of Protein Kinase Activity Cell Cycle Arrest Mitotic Cell Cycle Checkpoint Ras Protein Signal Transduction Regulation Of Mitotic Cell Cycle Negative Regulation Of Gene Expression Viral Process Cell Differentiation Neuron Differentiation Negative Regulation Of Cell Growth Androgen Receptor Signaling Pathway Sister Chromatid Biorientation Neuron Projection Development Maintenance Of Mitotic Sister Chromatid Cohesion Glial Cell Apoptotic Process Skeletal Muscle Cell Differentiation Neuron Maturation Enucleate Erythrocyte Differentiation Negative Regulation Of DNA-binding Transcription Factor Activity Regulation Of Lipid Kinase Activity Myoblast Differentiation Positive Regulation Of Macrophage Differentiation Negative Regulation Of Cell Cycle Positive Regulation Of Mitotic Metaphase/anaphase Transition Negative Regulation Of Smoothened Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Digestive Tract Development Cell Morphogenesis Involved In Neuron Differentiation Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Inflammatory Response Striated Muscle Cell Differentiation Cell Division Neuron Apoptotic Process Protein Localization To Chromosome, Centromeric Region Cellular Response To Xenobiotic Stimulus Negative Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Cohesin Loading Negative Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Regulation Of Centromere Complex Assembly Hepatocyte Apoptotic Process Negative Regulation Of Cold-induced Thermogenesis Negative Regulation Of Tau-protein Kinase Activity Positive Regulation Of Extracellular Matrix Organization Positive Regulation Of Collagen Fibril Organization Negative Regulation Of Myofibroblast Differentiation Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Transcription Regulatory Region DNA Binding Negative Regulation Of Apoptotic Signaling Pathway
Pathways		Regulation of HSF1-mediated heat shock response	Inhibition of replication initiation of damaged DNA by RB1/E2F1 Inhibition of replication initiation of damaged DNA by RB1/E2F1 Condensation of Prophase Chromosomes Formation of Senescence-Associated Heterochromatin Foci (SAHF) Oncogene Induced Senescence Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes Cyclin E associated events during G1/S transition Cyclin D associated events in G1 Cyclin A:Cdk2-associated events at S phase entry RUNX2 regulates osteoblast differentiation
Drugs		(2R,3R,4S,5R)-2-[6-amino-8-[(3,4-dichlorophenyl)methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol	Insulin Human Insulin Pork
Diseases			Bladder cancer Small cell lung cancer Glioma Osteosarcoma Breast cancer Esophageal cancer Hepatocellular carcinoma Chronic myeloid leukemia (CML)
GWAS			Birth weight ( 31043758 27680694) Chronic kidney disease ( 26420894) Offspring birth weight ( 31043758) Post bronchodilator FEV1/FVC ratio ( 26634245)
Interacting Genes		28 interacting genes: AR ARRB1 BCL2 BCL2L1 ESR1 HBEGF HSPA1A HSPA1B HSPA4 HSPA8 LRRK1 LRRK2 MAPT MET NR3C1 PDGFRB PPP1R15A PSMD1 PSMD2 PYGL RAF1 RARA RB1 SIAH1 STUB1 TRIM23 TRIM27 VDR	173 interacting genes: AATF ABL1 AHR ANKS1A AR ARID3B ATF2 BAG1 BDP1 BNC2 BRCA1 BRF1 CASP10 CASP2 CASP3 CASP6 CASP7 CASP8 CASP9 CBX1 CBX4 CCNA1 CCNA2 CCNB1 CCNC CCND1 CCND2 CCND3 CCNE1 CCNT2 CDC27 CDK1 CDK14 CDK2 CDK3 CDK4 CDK5 CDK6 CDK9 CDKN1A CDKN1C CEBPA CEBPB CEBPD CEBPE CHEK1 CHN2 CLNK CREG1 CTBP1 CUX1 DGKZ DNMT1 DYRK1A E2F1 E2F2 E2F3 E2F4 E4F1 EID1 ELF1 ENC1 EP300 FOS FRK GTF3C2 HBP1 HDAC1 HDAC3 HIF1A HMGA2 HMGB1 HSPA8 ID2 INS IRF3 JUN KAT2B KAT5 KDM4A KDM5A KDM5B KMT5C L3MBTL1 LIN54 LIN9 LMNA MAPK1 MAPK9 MCM7 MDM2 MDM4 MNAT1 MNDA MORF4L1 MORF4L2 MRPS18B MYC MYOD1 NCOA6 NDC80 NEFM ORC1 PA2G4 PAX2 PAX5 PAX6 PELP1 PHB PIK3R1 PIK3R3 PLA2G12A PML POLA1 PPARG PPIA PPP1CA PPP1CB PPP1CC PPP1R26 PRDM2 PRKCB PRKRA PRMT2 PSMD10 PURA RABGAP1L RACK1 RAF1 RBAK RBBP4 RBBP5 RBBP6 RBBP7 RBBP8 RBBP9 RING1 RINT1 RNF123 RNF40 RUNX2 SERPINB2 SKP2 SMARCA4 SMARCB1 SMYD2 SNAPC1 SNAPC3 SNW1 SP1 SP3 SPI1 SPIB STAT3 SUV39H1 TAF1 TASOR TBP TFAP2A TGM2 THOC1 TMPO TOP2A TP53 TRAP1 TRIM27 TRIP11 UBE2I UBTF USP4 USP7 VDR ZBTB16
Entrez ID		573	5925
HPRD ID		03292	01574
Ensembl ID		ENSG00000107262	ENSG00000139687
Uniprot IDs		Q99933	A0A024RDV3 P06400
PDB IDs		1HX1 1WXV 3FZF 3FZH 3FZK 3FZL 3FZM 3LDQ 3M3Z 5AQF 5AQG 5AQH 5AQI 5AQJ 5AQK 5AQL 5AQM 5AQN 5AQO 5AQP 5AQQ 5AQR 5AQS 5AQT 5AQU 5AQV	1AD6 1GH6 1GUX 1H25 1N4M 1O9K 1PJM 2AZE 2QDJ 2R7G 3N5U 3POM 4CRI 4ELJ 4ELL
Enriched GO Terms of Interacting Partners?
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