TIGAR and RPL11

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		TIGAR	RPL11
Description		TP53 induced glycolysis regulatory phosphatase	ribosomal protein L11
Image
GO Annotations	Cellular Component	Intracellular Nucleus Cytoplasm Mitochondrial Outer Membrane Cytosol	Nucleoplasm Nucleolus Cytoplasm Cytosol Membrane Cytosolic Large Ribosomal Subunit Protein-containing Complex Polysomal Ribosome Extracellular Exosome
	Molecular Function	Bisphosphoglycerate 2-phosphatase Activity Fructose-2,6-bisphosphate 2-phosphatase Activity Protein Binding	RNA Binding Structural Constituent Of Ribosome Protein Binding 5S RRNA Binding Ubiquitin Protein Ligase Binding Ubiquitin Ligase Inhibitor Activity
	Biological Process	Response To Ischemia Fructose 2,6-bisphosphate Metabolic Process Autophagy Apoptotic Process Cellular Response To DNA Damage Stimulus Response To Xenobiotic Stimulus Response To Gamma Radiation Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Dephosphorylation Fructose 1,6-bisphosphate Metabolic Process Negative Regulation Of Programmed Cell Death Regulation Of Pentose-phosphate Shunt Positive Regulation Of DNA Repair Negative Regulation Of Glycolytic Process Intestinal Epithelial Cell Development Cellular Response To Cobalt Ion Cellular Response To Hypoxia Negative Regulation Of Neuron Death Negative Regulation Of Mitophagy Regulation Of Response To DNA Damage Checkpoint Signaling Positive Regulation Of Hexokinase Activity Negative Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate Negative Regulation Of Reactive Oxygen Species Metabolic Process	Ribosomal Large Subunit Assembly Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Cytoplasmic Translation RRNA Processing Translation Translational Initiation Protein Targeting SRP-dependent Cotranslational Protein Targeting To Membrane Positive Regulation Of Gene Expression Viral Transcription Positive Regulation Of Protein Binding Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Localization To Nucleus Ribosomal Large Subunit Biogenesis Protein Stabilization Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Negative Regulation Of Ubiquitin Protein Ligase Activity Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Protein Neddylation
Pathways		TP53 Regulates Metabolic Genes	L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs			Alpha-Hydroxy-Beta-Phenyl-Propionic Acid Anisomycin Puromycin
Diseases			Diamond-Blackfan anemia (DBA)
GWAS
Interacting Genes		2 interacting genes: APP RPL11	19 interacting genes: APP ARFGAP1 BLMH CAMK2B CDKN2A HP HSPB2 IGF1R KRT40 KRTAP10-7 LIG4 MDM2 PAIP2 PML SENP1 STAT3 TIGAR TP73 UBE2I
Entrez ID		57103	6135
HPRD ID		12610	10364
Ensembl ID		ENSG00000078237	ENSG00000142676
Uniprot IDs		Q9NQ88	P62913 Q5VVD0
PDB IDs		3DCY	4UG0 4V6X 4XXB 5AJ0 5LKS 5T2C 6EK0 6IP5 6IP6 6IP8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP
Enriched GO Terms of Interacting Partners?
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