KNL1 and BUB1

Number of citations of the paper that reports this interaction (PubMedID 26186194)
367

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid)

		KNL1	BUB1
Description		kinetochore scaffold 1	BUB1 mitotic checkpoint serine/threonine kinase
Image
GO Annotations	Cellular Component	Condensed Chromosome Kinetochore Acrosomal Vesicle Nucleus Nucleoplasm Cytosol Nuclear Body	Kinetochore Condensed Chromosome Kinetochore Condensed Nuclear Chromosome Kinetochore Condensed Nuclear Chromosome Outer Kinetochore Nucleoplasm Cytosol Membrane
	Molecular Function	Protein Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding
	Biological Process	Acrosome Assembly Attachment Of Spindle Microtubules To Kinetochore Negative Regulation Of Phosphatase Activity CENP-A Containing Nucleosome Assembly Protein Localization To Kinetochore Cell Division	Protein Phosphorylation Apoptotic Process Regulation Of Sister Chromatid Cohesion Mitotic Cell Cycle Checkpoint Mitotic Spindle Assembly Checkpoint Cell Proliferation Viral Process Cell Division Meiotic Sister Chromatid Cohesion, Centromeric Regulation Of Chromosome Segregation
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Deposition of new CENPA-containing nucleosomes at the centromere Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Anxiety and stress-related disorders ( 31116379)
Interacting Genes		6 interacting genes: BUB1 BUB1B DSN1 MIS12 PPP1CA TTK	18 interacting genes: AP1B1 AP2B1 AP3B1 AP4B1 APC ARIH2 BUB3 CDC20 CDK1 CRK EIF4EBP1 FBXO7 HDAC1 KNL1 PLK1 RAE1 RDH12 SVIL
Entrez ID		57082	699
HPRD ID		10634	03907
Ensembl ID		ENSG00000137812	ENSG00000169679
Uniprot IDs		Q8NG31	B4DYG2 O43683
PDB IDs		3SI5 4A1G 4NF9 4NFA	2LAH 4A1G 4QPM 4R8Q 5DMZ 6F7B
Enriched GO Terms of Interacting Partners?
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