LXN and DPYD

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		LXN	DPYD
Description		latexin	dihydropyrimidine dehydrogenase
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Cytoplasm	Cytoplasm Cytosol
	Molecular Function	Protein Binding Metalloendopeptidase Inhibitor Activity Heparin Binding	Uracil Binding Protein Binding Dihydropyrimidine Dehydrogenase (NADP+) Activity Protein Homodimerization Activity Metal Ion Binding Flavin Adenine Dinucleotide Binding NADP Binding Iron-sulfur Cluster Binding 4 Iron, 4 Sulfur Cluster Binding
	Biological Process	Inflammatory Response Negative Regulation Of Endopeptidase Activity Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain	Purine Nucleobase Catabolic Process Pyrimidine Nucleobase Catabolic Process Thymine Catabolic Process Uracil Catabolic Process Thymidine Catabolic Process Beta-alanine Biosynthetic Process Pyrimidine Nucleoside Catabolic Process Oxidation-reduction Process
Pathways			Pyrimidine catabolism
Drugs			(5s)-5-Iododihydro-2,4(1h,3h)-Pyrimidinedione Nadph Dihydro-Nicotinamide-Adenine-Dinucleotidephosphate 6-Carboxymethyluracil Flavin adenine dinucleotide Riboflavin Monophosphate Uracil Eniluracil 5-Iodouracil Gimeracil
Diseases			Dihydropyrimidine dehydrogenase deficiency
GWAS		Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143)	Adverse response to drug ( 30420678) Anthropometric traits (multi-trait analysis) ( 30166351) Anxiety/tension (special factor of neuroticism) ( 30867560) Autism spectrum disorder or schizophrenia ( 28540026) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Body mass index ( 25673413 29273807) Borderline personality disorder ( 28632202) Chronotype ( 30696823) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Coronary artery disease ( 29212778) Extremely high intelligence ( 29520040) Face memory ( 31596458) Feeling nervous ( 29500382) Gastroesophageal reflux disease ( 31527586) Heel bone mineral density ( 30598549) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Irritable mood ( 29500382) Menarche (age at onset) ( 25231870) Metabolite levels ( 23823483) Methadone dose in opioid dependence ( 28115739) Platelet count ( 21507922) Regular attendance at a pub or social club ( 29970889) Schizophrenia ( 25056061 29483656 22688191 30285260 23974872) Sleep duration ( 30531941) Sleep duration (short sleep) ( 30846698) Waist-to-hip ratio adjusted for BMI ( 28552196)
Interacting Genes		6 interacting genes: DPYD GSG1L MAGEA8 TMEM14A TRIM39 ZKSCAN4	4 interacting genes: CLK1 CSDE1 GOPC LXN
Entrez ID		56925	1806
HPRD ID		14327	02036
Ensembl ID		ENSG00000079257	ENSG00000188641
Uniprot IDs		Q9BS40	Q12882
PDB IDs		2BO9
Enriched GO Terms of Interacting Partners?
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