PNO1 and IGFBP5

Number of citations of the paper that reports this interaction (PubMedID 16169070)
820

Data Source:
HPRD (two hybrid)

		PNO1	IGFBP5
Description		partner of NOB1 homolog	insulin like growth factor binding protein 5
Image
GO Annotations	Cellular Component	Nucleoplasm Nucleolus Cytosol	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Insulin-like Growth Factor Binding Protein Complex Insulin-like Growth Factor Ternary Complex
	Molecular Function	RNA Binding	Fibronectin Binding Protein Binding Insulin-like Growth Factor I Binding Insulin-like Growth Factor II Binding
	Biological Process		Regulation Of Cell Growth Osteoblast Differentiation Signal Transduction Female Pregnancy Aging Negative Regulation Of Smooth Muscle Cell Migration Negative Regulation Of Translation Negative Regulation Of Cell Migration Hair Follicle Morphogenesis Intracellular Signal Transduction Glucose Homeostasis Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Post-translational Protein Modification Cellular Protein Metabolic Process Type B Pancreatic Cell Proliferation Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Growth Lung Alveolus Development Negative Regulation Of Smooth Muscle Cell Proliferation Striated Muscle Cell Differentiation Positive Regulation Of Protein Kinase B Signaling Mammary Gland Involution Response To Growth Hormone Cellular Response To CAMP Cellular Response To Organic Cyclic Compound Negative Regulation Of Muscle Tissue Development Negative Regulation Of Skeletal Muscle Hypertrophy Positive Regulation Of Vascular Smooth Muscle Cell Proliferation Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration
Pathways		rRNA modification in the nucleus and cytosol Major pathway of rRNA processing in the nucleolus and cytosol	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs
Diseases
GWAS			Blood protein levels ( 30072576 29875488) Breast cancer ( 29059683) Creatinine levels ( 29403010) Estimated glomerular filtration rate ( 30604766) FEV1 ( 30804560) Glomerular filtration rate ( 27588450 29403010) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Height ( 31562340) Hypothyroidism ( 27182965) Lung function (FEV1/FVC) ( 30804560) Metabolite levels ( 23823483) Mitral valve prolapse ( 26301497) Pulse pressure ( 27841878) Serum thyroid-stimulating hormone levels ( 25436638) Thyroid hormone levels ( 23408906) Visceral fat ( 22589738)
Interacting Genes		9 interacting genes: ATP5F1C FRZB GSTP1 IGFBP5 KLF6 PDPK1 RXRG SGSM2 SUPT5H	21 interacting genes: ADAM12 BAG6 CREB3 CSDE1 F2 FHL2 FN1 IGF1 IGF2 IGFALS KPNB1 LMNA LTBP1 PAPPA2 PNO1 RASSF1 SERPINE1 SPP1 TF THBS1 VTN
Entrez ID		56902	3488
HPRD ID		14250	00901
Ensembl ID		ENSG00000115946	ENSG00000115461
Uniprot IDs		Q9NRX1	P24593
PDB IDs		6G18 6G4S 6G4W 6G51 6G53 6G5I	1BOE 1H59
Enriched GO Terms of Interacting Partners?
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