PSEN1 and APH1B

  • Number of citations of the paper that reports this interaction (PubMedID 12471034)
  • 45
  • Data Source:
  • HPRD (in vivo)

PSEN1

APH1B

Description presenilin 1 aph-1 homolog B, gamma-secretase subunit
Image No pdb structure
GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Alzheimer's disease or family history of Alzheimer's disease ( 30617256)
  • Estimated glomerular filtration rate ( 31152163)
  • Family history of Alzheimer's disease ( 30617256)
  • Metabolite levels ( 23823483)
  • Myopia ( 27182965)
  • Response to fenofibrate (triglyceride levels) ( 27002377)
  • Spherical equivalent or myopia (age of diagnosis) ( 29808027)
Interacting Genes 91 interacting genes: ACTN1 AP1M2 APBA1 APH1A APH1B APOE APP BACE1 BCL2 BCL2L1 CASP1 CASP3 CASP4 CASP6 CASP7 CASP8 CDH1 CDK5 CFL1 CIB1 CTNNA1 CTNNB1 CTNND1 CTNND2 CYP2C18 CYP2C8 DLL1 DOCK3 ECSIT EFHD1 EFNB2 ENSA EPB41L3 ERN1 ETFA FBXL12 FBXW7 FGF13 FLNA FLNB GAPDH GCDH GDI1 GFAP GSK3B HERPUD1 HMGB1 ICAM5 ITSN2 JUP KANK2 KCNIP3 KCNIP4 MAPK9 MAPT METTL2B MTCH1 NCSTN NOS3 NOTCH1 NOTCH2 NOTCH3 NOTCH4 OXCT1 PDCD4 PIK3R1 PKP4 PRAM1 PRDX2 PRKACA PRKCZ PSENEN PSMA5 PSMB1 RAB11A RAB3A RAD23A RHEB RMDN3 RNF32 RYR2 SCAF11 SCN1A ST13 STAMBPL1 TCF7L2 TDP2 TUBA1B UBQLN1 UMPS YME1L1 3 interacting genes: NCSTN PSEN1 PSEN2
Entrez ID 5663 83464
HPRD ID 00087 06361
Ensembl ID ENSG00000080815 ENSG00000138613
Uniprot IDs A0A024R6A3 A0A0S2Z4D2 P49768 Q8WW43
PDB IDs 2KR6 4UIS 5A63 5FN2 5FN3 5FN4 5FN5 6IDF 6IYC
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?