MAP2K5 and ASRGL1

Number of citations of the paper that reports this interaction (PubMedID 21900206)
114

Data Source:
BioGRID (two hybrid)

		MAP2K5	ASRGL1
Description		mitogen-activated protein kinase kinase 5	asparaginase and isoaspartyl peptidase 1
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Spindle Cytosol	Photoreceptor Inner Segment Nucleus Cytoplasm Cytosol
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Metal Ion Binding	N4-(beta-N-acetylglucosaminyl)-L-asparaginase Activity Asparaginase Activity Beta-aspartyl-peptidase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Activation Of MAPK Activity Signal Transduction Regulation Of Mitotic Cell Cycle Heart Development Peptidyl-tyrosine Phosphorylation Signal Transduction By Protein Phosphorylation Positive Regulation Of Cell Growth Stress-activated Protein Kinase Signaling Cascade Negative Regulation Of NF-kappaB Transcription Factor Activity Activation Of Protein Kinase Activity Negative Regulation Of Heterotypic Cell-cell Adhesion Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Interleukin-8 Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Protein Metabolic Process Negative Regulation Of Response To Cytokine Stimulus ERK5 Cascade Cellular Response To Growth Factor Stimulus Cellular Response To Laminar Fluid Shear Stress Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Proteolysis L-phenylalanine Catabolic Process Asparagine Catabolic Process Via L-aspartate
Pathways		Signalling to ERK5	Phenylalanine metabolism
Drugs			L-Aspartic Acid L-Asparagine
Diseases
GWAS		Bipolar disorder or body mass index ( 31754094) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) Body mass index ( 28552196 22344219 26961502 24861553 28892062 25673413 20935630 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index in physically active individuals ( 28448500) Dental caries (decayed and filled deciduous teeth) ( 31533690) Menarche (age at onset) ( 25231870) Motion sickness ( 25628336) Obesity ( 23563607) Restless legs syndrome ( 17637780 29029846 21779176) Smoking status (ever vs never smokers) ( 30643258) Type 2 diabetes ( 30297969) Verbal declarative memory ( 25648963) Waist circumference ( 25673412) Weight ( 28552196)	Body fat mass ( 28552196) Chronic obstructive pulmonary disease-related biomarkers ( 23144326) Heel bone mineral density ( 30598549) Trunk fat mass ( 28552196) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		49 interacting genes: AKT1 ARAF ARNT ASRGL1 BAD BECN1 CCND2 CD44 CDC42BPB CDK4 CDK6 CDKN2A CDKN2B CDKN2C EPHA2 ERBB2 ESRRA FGFR4 FZR1 GLIS2 GRM1 HGF HIF1A LATS2 LNX2 MAP2K3 MAP2K6 MAP3K2 MAP3K3 MAPK7 MDM4 MET MYC NF2 PARD6A PDGFRA PRKCI PRKCZ RAF1 RPL28 SQSTM1 STAMBP STK11 TEAD2 TERT TP53 TSC1 XRCC6 YWHAZ	4 interacting genes: GSK3B MAP2K5 MAPK8IP2 TAB1
Entrez ID		5607	80150
HPRD ID		03951	07006
Ensembl ID		ENSG00000137764	ENSG00000162174
Uniprot IDs		A0A024R5X5 A0A024R5Y2 Q13163	A0A024R573 Q7L266
PDB IDs		2NPT 2O2V 4IC7	3TKJ 4ET0 4O0C 4O0D 4O0E 4O0F 4O0G 4O0H 4OSX 4OSY 4PVP 4PVQ 4PVR 4PVS 4ZM9
Enriched GO Terms of Interacting Partners?
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