CENPJ and TUBG1

Number of citations of the paper that reports this interaction (PubMedID 11003675)
56

Data Source:
HPRD (in vivo)

		CENPJ	TUBG1
Description		centromere protein J	tubulin gamma 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Centrosome Centriole Cytosol Microtubule Plasma Membrane Gamma-tubulin Small Complex Ciliary Basal Body	Pericentriolar Material Condensed Nuclear Chromosome Gamma-tubulin Complex Nucleus Cytoplasm Centrosome Centriole Spindle Polar Microtubule Cytosol Microtubule Cytoplasmic Microtubule Cell Leading Edge Ciliary Basal Body Apical Part Of Cell Recycling Endosome Non-motile Cilium
	Molecular Function	Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Tubulin Binding Protein Kinase Binding Protein Domain Specific Binding Identical Protein Binding Gamma-tubulin Binding	GTPase Activity Structural Constituent Of Cytoskeleton Protein Binding GTP Binding Identical Protein Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Microtubule Nucleation Centriole Replication Smoothened Signaling Pathway Regulation Of G2/M Transition Of Mitotic Cell Cycle Astral Microtubule Nucleation Motile Cilium Assembly Positive Regulation Of JAK-STAT Cascade Regulation Of Centriole Replication Microtubule Polymerization Cell Division Centriole Elongation Ciliary Basal Body-plasma Membrane Docking Positive Regulation Of Non-motile Cilium Assembly Negative Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Centriole Elongation Positive Regulation Of Establishment Of Protein Localization Non-motile Cilium Assembly	Mitotic Sister Chromatid Segregation G2/M Transition Of Mitotic Cell Cycle Meiotic Spindle Organization Microtubule Cytoskeleton Organization Mitotic Cell Cycle Microtubule-based Process Microtubule Nucleation Mitotic Spindle Organization Regulation Of G2/M Transition Of Mitotic Cell Cycle Cytoplasmic Microtubule Organization Ciliary Basal Body-plasma Membrane Docking
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain AURKA Activation by TPX2	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs			Vinblastine
Diseases		Seckel syndrome Primary microcephaly (MCPH)
GWAS
Interacting Genes		14 interacting genes: ATN1 CIC CREBBP EPB41 FBXO7 GFI1B LAG3 LYST MTDH STAT5A STAT5B TUBG1 YWHAG YWHAZ	29 interacting genes: APP BRCA1 CENPJ CNTN2 CUL4A DDX41 IKBKG KIF14 KRT18 KRT19 MARK4 NAPG NDE1 OLA1 PCNT PIK3R1 PLK1 PXN RACGAP1 RACK1 RASSF1 RNF19A RPGR SPATC1 TUBA1B TUBA3C TUBB4B TUBGCP3 TUBGCP4
Entrez ID		55835	7283
HPRD ID		09876	01853
Ensembl ID		ENSG00000151849	ENSG00000131462
Uniprot IDs		A8K8P1 F6VUX8 Q9HC77	P23258
PDB IDs		5EIB 5ITZ	1Z5V 1Z5W 3CB2
Enriched GO Terms of Interacting Partners?
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