SCN3B and NLRX1

		SCN3B	NLRX1
Description		sodium voltage-gated channel beta subunit 3	NLR family member X1
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GO Annotations	Cellular Component	Voltage-gated Sodium Channel Complex Plasma Membrane Integral Component Of Membrane Z Disc	Mitochondrion Mitochondrial Outer Membrane Plasma Membrane Cell Junction
	Molecular Function	Voltage-gated Ion Channel Activity Protein Binding Sodium Channel Regulator Activity Sodium Channel Inhibitor Activity Ion Channel Binding Voltage-gated Sodium Channel Activity Involved In Cardiac Muscle Cell Action Potential	Protein Binding ATP Binding
	Biological Process	Sodium Ion Transport Nervous System Development Positive Regulation Of Heart Rate Positive Regulation Of Sodium Ion Transport Sensory Perception Of Pain Sodium Ion Transmembrane Transport Membrane Depolarization Cardiac Muscle Contraction Regulation Of Atrial Cardiac Muscle Cell Membrane Depolarization Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization Protein Localization To Plasma Membrane Cardiac Muscle Cell Action Potential Involved In Contraction Ventricular Cardiac Muscle Cell Action Potential Membrane Depolarization During Action Potential Membrane Depolarization During Cardiac Muscle Cell Action Potential Atrial Cardiac Muscle Cell Action Potential SA Node Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Regulation Of Sodium Ion Transmembrane Transporter Activity	Viral Process Negative Regulation Of Type I Interferon Production Negative Regulation Of Interferon-beta Production Negative Regulation Of Interleukin-6 Production Intracellular Signal Transduction Negative Regulation Of RIG-I Signaling Pathway Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Negative Regulation Of Innate Immune Response Negative Regulation Of Inflammatory Response
Pathways		Interaction between L1 and Ankyrins Phase 0 - rapid depolarisation	DDX58/IFIH1-mediated induction of interferon-alpha/beta Negative regulators of DDX58/IFIH1 signaling
Drugs		Valproic Acid Zonisamide Brivaracetam
Diseases		Brugada syndrome (BRS)
GWAS		Chronic lymphocytic leukemia ( 28165464 24292274 23770605) Response to citalopram or escitalopram in depression ( 27622933)
Interacting Genes		2 interacting genes: NFASC NLRX1	9 interacting genes: ABCG4 BUD13 C1QTNF5 IFT46 PDZD3 SARM1 SCN3B TMEM25 TMPRSS4
Entrez ID		55800	79671
HPRD ID		10497	17640
Ensembl ID		ENSG00000166257	ENSG00000160703
Uniprot IDs		A0A024R3H7 Q9NY72	Q86UT6
PDB IDs		4L1D	3UN9
Enriched GO Terms of Interacting Partners?
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