ARHGEF40 and TAC1

Number of citations of the paper that reports this interaction (PubMedID 16169070)
820

Data Source:
HPRD (two hybrid)

		ARHGEF40	TAC1
Description		Rho guanine nucleotide exchange factor 40	tachykinin precursor 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytosol	Extracellular Region Extracellular Space Cell Plasma Membrane Axon Neuronal Cell Body Synapse
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity	Substance P Receptor Binding
	Biological Process		Positive Regulation Of Acute Inflammatory Response Inflammatory Response G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Tachykinin Receptor Signaling Pathway Neuropeptide Signaling Pathway Cell-cell Signaling Chemical Synaptic Transmission Insemination Long-term Memory Regulation Of Blood Pressure Associative Learning Detection Of Abiotic Stimulus Response To Hormone Negative Regulation Of Heart Rate Positive Regulation Of Epithelial Cell Migration Sensory Perception Of Pain Positive Regulation Of Synaptic Transmission, Cholinergic Positive Regulation Of Synaptic Transmission, GABAergic Response To Lipopolysaccharide Positive Regulation Of Renal Sodium Excretion Response To Morphine Positive Regulation Of Action Potential Positive Regulation Of Ossification Positive Regulation Of Saliva Secretion Response To Pain Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Stress Fiber Assembly Cellular Response To Nerve Growth Factor Stimulus Positive Regulation Of Corticosterone Secretion
Pathways		NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events	Tachykinin receptors bind tachykinins G alpha (q) signalling events
Drugs
Diseases
GWAS		Hematocrit ( 27863252) Pediatric nonalcoholic steatohepatitis ( 28918882) Resting heart rate ( 27798624)	Adventurousness ( 30643258) Adverse response to radiation therapy ( 23719583) Blood protein levels ( 30072576) Feeling nervous ( 29500382) General risk tolerance (MTAG) ( 30643258) Regular attendance at a religious group ( 29970889) Response to platinum-based agents ( 22020760) Squamous cell lung carcinoma ( 28604730)
Interacting Genes		6 interacting genes: APP CBY2 MAPT MYCBP STC2 TAC1	10 interacting genes: ARHGEF40 BAG6 CENPB FN1 MEP1A PREP TACR1 TACR2 TACR3 XRCC6
Entrez ID		55701	6863
HPRD ID		13335	08876
Ensembl ID		ENSG00000165801	ENSG00000006128
Uniprot IDs		Q8TER5	P20366 Q9Y494
PDB IDs			2B19 2KS9 2KSA 2KSB 4HOM
Enriched GO Terms of Interacting Partners?
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