POMGNT1 and ZBTB18

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		POMGNT1	ZBTB18
Description		protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-)	zinc finger and BTB domain containing 18
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Integral Component Of Membrane Integral Component Of Golgi Membrane	Nuclear Chromosome Nucleus Nuclear Speck
	Molecular Function	Protein Binding Acetylglucosaminyltransferase Activity Manganese Ion Binding Beta-1,3-galactosyl-O-glycosyl-glycoprotein Beta-1,3-N-acetylglucosaminyltransferase Activity	DNA Binding DNA-binding Transcription Factor Activity Transcription Coactivator Activity Protein Binding Sequence-specific DNA Binding Metal Ion Binding
	Biological Process	Protein O-linked Glycosylation O-glycan Processing	Negative Regulation Of Transcription By RNA Polymerase II Cellular Response To DNA Damage Stimulus Skeletal Muscle Tissue Development Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3 O-linked glycosylation
Drugs
Diseases		Congenital muscular dystrophies (CMD/MDC), including: Merosin-deficient CMD (MDC1A); Ullrich CMD (UCMD); Integrin alpha7-deficient CMD; CMD with joint hyperlaxity (CMDH); CMD with epidermolysis bullosa; Walker-Warburg syndrome (WWS); Muscle-eye-brain disease (MEB); Fukuyama CMD (FCMD); CMD with muscle hypertrophy (MDC1C); CMD with severe intellectual impairment and abnormal glycosylation (MDC1D); Rigid spine syndrome (RSS); LMNA-deficient CMD; CMD with respiratory failure and muscle hypertrophy (MDC1B); Bethlem myopathy Dystroglycanopathy; Walker-Warburg syndrome (WWS); Muscle-eye-brain disease (MEB); Fukuyama congenital muscular dystrophy (FCMD); Congenital muscular dystrophy with muscle hypertrophy (MDC1C); Congenital muscular dystrophy with severe intellectual impairment and abnormal glycosylation (MDC1D) Limb-girdle muscular dystrophy (LGMD)
GWAS		Body mass index ( 26426971)	Adventurousness ( 30643258) General risk tolerance (MTAG) ( 30643258) Mercury levels ( 26025379)
Interacting Genes		5 interacting genes: BRCA1 CXCL8 LNX1 SOX6 ZBTB18	7 interacting genes: CTBP1 CTBP2 DNMT3A DNMT3B PAK1 POMGNT1 TSN
Entrez ID		55624	10472
HPRD ID		09493	12231
Ensembl ID		ENSG00000085998	ENSG00000179456
Uniprot IDs		B7Z7F2 B7Z7Q4 Q8WZA1	Q99592
PDB IDs		5GGF 5GGG 5GGI 5GGJ 5GGK 5GGL 5GGN 5GGO 5GGP 5XFC
Enriched GO Terms of Interacting Partners?
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