PRKAA1 and MDM4

  • Number of citations of the paper that reports this interaction (PubMedID 24190973)
  • 33
  • Data Source:
  • BioGRID (enzymatic study)

PRKAA1

MDM4

Description protein kinase AMP-activated catalytic subunit alpha 1 MDM4 regulator of p53
Image
GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Breast cancer ( 23535733 27117709)
  • Breast cancer (estrogen-receptor negative) ( 27117709 29058716)
  • Breast cancer (estrogen-receptor negative, progesterone-receptor negative, and human epidermal growth factor-receptor negative) ( 24325915)
  • Breast Cancer in BRCA1 mutation carriers ( 23544013)
  • Cognitive performance ( 19734545)
  • Diastolic blood pressure ( 27618452 30578418)
  • Diastolic blood pressure (cigarette smoking interaction) ( 29455858)
  • Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962)
  • Glioma ( 28346443)
  • Non-glioblastoma glioma ( 28346443)
  • Prostate cancer ( 23535732)
  • Regular attendance at a religious group ( 29970889)
  • Systolic blood pressure ( 27618452)
Interacting Genes 67 interacting genes: ABI2 ACACA BHLHE40 CAB39 CAMKK1 CDX4 CFTR CHEK1 CRTC2 CTBP1 DVL2 EEF2K EPM2A FANCA FNIP1 GATA1 GOLGA2 GRIK2 HDAC5 HMBOX1 HOMEZ IKZF3 INO80E KIF16B KRT40 L3MBTL3 MDM4 MORC4 MTOR MTUS2 PASK PFKFB2 PHC2 PNMA5 PPM1A PPM1E PPM1F PPP2CA PRKAB1 PRKAB2 PRKAG1 PRKAG3 PSMD11 RACK1 RAD54B RAF1 RBPMS RFX6 RIMBP3 ROPN1 RPTOR SRPK2 SSX2IP STK11 THAP1 TLE5 TOMM34 TRIM27 TRIP6 TSC2 TSC22D4 TXNIP UBXN11 ULK1 VPS37B VPS52 ZBED1 58 interacting genes: AKT1 APP ARF1 ATM BECN1 CAPN7 CASP3 CBLC CD160 CD44 CDK1 CDK4 CDKN2A CDKN2B CHEK1 CHEK2 CSNK1A1 E2F1 EP300 EPHA2 FGFR4 GLIS2 HGF LATS2 LRSAM1 MAGEA1 MAP2K5 MDM2 MKRN3 MNAT1 NF2 PELI1 PRKAA1 RAD54B RB1 RNF115 S100B SFN SMAD3 SMAD4 SMARCA2 TP53 TP63 TP73 TRIM46 TRIM55 UBC UBE2D1 UBE2D2 UBE2D3 USP7 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ ZKSCAN4
Entrez ID 5562 4194
HPRD ID 04115 04082
Ensembl ID ENSG00000132356 ENSG00000198625
Uniprot IDs Q13131 A0A087WTR9 A0A087WUE3 A0A087WZ58 O15151 Q59FS6 Q68DC0
PDB IDs 4RED 4RER 4REW 5EZV 6C9F 6C9G 6C9H 6C9J 2CR8 2MWY 2N06 2N0U 2N0W 2N14 2VJE 2VJF 2VYR 3DAB 3EQY 3FDO 3FE7 3FEA 3JZO 3JZP 3JZQ 3LBJ 3MQR 3U15 4RXZ 5MNJ 5UML 5VK1 6Q9Q 6Q9S 6Q9U 6Q9W 6Q9Y
Enriched GO Terms of Interacting Partners?
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