CDCA7L and EIF4A3

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		CDCA7L	EIF4A3
Description		cell division cycle associated 7 like	eukaryotic translation initiation factor 4A3
Image
GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm Nucleolus Cytosol	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Membrane Nuclear Speck Dendrite Exon-exon Junction Complex Neuronal Cell Body U2-type Catalytic Step 1 Spliceosome Catalytic Step 2 Spliceosome Glutamatergic Synapse Postsynaptic Cytosol
	Molecular Function	Protein Binding	RNA Binding RNA Helicase Activity MRNA Binding Protein Binding ATP Binding Poly(A) Binding Selenocysteine Insertion Sequence Binding RNA Stem-loop Binding Ribonucleoprotein Complex Binding Translation Regulator Activity
	Biological Process	Regulation Of Transcription, DNA-templated Positive Regulation Of Cell Proliferation	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay MRNA Splicing, Via Spliceosome RRNA Processing RNA Export From Nucleus MRNA Export From Nucleus Associative Learning Response To Organic Cyclic Compound Negative Regulation Of Translation MRNA 3'-end Processing Exploration Behavior Positive Regulation Of Translation Embryonic Cranial Skeleton Morphogenesis Cellular Response To Selenite Ion Negative Regulation Of Excitatory Postsynaptic Potential Regulation Of Translation At Postsynapse, Modulating Synaptic Transmission Negative Regulation Of Selenocysteine Incorporation Negative Regulation Of Selenocysteine Insertion Sequence Binding Cellular Response To Brain-derived Neurotrophic Factor Stimulus
Pathways			ISG15 antiviral mechanism Transport of Mature mRNA derived from an Intron-Containing Transcript Deadenylation of mRNA mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS		Breast cancer ( 29059683) Height ( 20189936) Multiple myeloma ( 26007630) Multiple myeloma and monoclonal gammopathy ( 26007630) Pre-treatment viral load in HIV-1 infection ( 31219150) Squamous cell lung carcinoma ( 28604730) Urate levels in obese individuals ( 25811787)	High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Immature fraction of reticulocytes ( 27863252) Myocardial infarction ( 26708285) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252)
Interacting Genes		38 interacting genes: ABT1 ANKRD11 AXIN1 BEND7 BYSL CARD9 CCDC33 CEP70 CTNNBL1 DAXX DEDD2 EIF4A3 FAM9B ING5 KRTAP10-7 LMO1 MDFI MFAP1 MLH1 MORN3 MYC NOP2 PPP1R16B PRDM14 PRPF31 SSX2IP STX11 SUV39H1 TADA2A TFPT TRAF3IP3 TRIM42 UBL4A UTP3 VDR ZGPAT ZNF250 ZNF821	12 interacting genes: CASC3 CCDC174 CDCA7L CWC22 ESR1 MAGOH NXF1 PDCD4 RBM8A UPF1 UPF3B YWHAQ
Entrez ID		55536	9775
HPRD ID		11481	06482
Ensembl ID		ENSG00000164649	ENSG00000141543
Uniprot IDs		A0A024RA51 A8K8X5 Q96GN5	A0A024R8W0 I3L3H2 P38919
PDB IDs		5YI9 6EMO	2HXY 2HYI 2J0Q 2J0S 2J0U 2XB2 3EX7 4C9B 5MQF 5XJC 5YZG 6ICZ 6QDV
Enriched GO Terms of Interacting Partners?
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