PRG2 and CSF2

Number of citations of the paper that reports this interaction (PubMedID 7727786)
16

Data Source:
HPRD (in vitro)

		PRG2	CSF2
Description		proteoglycan 2, pro eosinophil major basic protein	colony stimulating factor 2
Image
GO Annotations	Cellular Component	Extracellular Region Transport Vesicle Collagen-containing Extracellular Matrix Extracellular Exosome Ficolin-1-rich Granule Lumen	Extracellular Region Extracellular Space Intracellular Membrane-bounded Organelle
	Molecular Function	Heparin Binding Extracellular Matrix Structural Constituent Conferring Compression Resistance Carbohydrate Binding	Cytokine Activity Granulocyte Macrophage Colony-stimulating Factor Receptor Binding Protein Binding Growth Factor Activity
	Biological Process	Defense Response To Bacterium Neutrophil Degranulation	MAPK Cascade Histamine Secretion Embryonic Placenta Development Immune Response Positive Regulation Of Cell Proliferation Positive Regulation Of Gene Expression Positive Regulation Of Macrophage Derived Foam Cell Differentiation Cytokine-mediated Signaling Pathway Myeloid Cell Differentiation Macrophage Differentiation Positive Regulation Of Interleukin-23 Production Response To Silicon Dioxide Response To Fluid Shear Stress Epithelial Fluid Transport Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Myeloid Dendritic Cell Differentiation Regulation Of Circadian Sleep/wake Cycle, Sleep Regulation Of Myeloid Cell Differentiation Negative Regulation Of Transcription, DNA-templated Cellular Response To Lipopolysaccharide Positive Regulation Of Podosome Assembly Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus Dendritic Cell Differentiation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Neutrophil degranulation	Interleukin-3, Interleukin-5 and GM-CSF signaling RAF/MAP kinase cascade Interleukin-10 signaling RUNX1 regulates transcription of genes involved in differentiation of myeloid cells Interleukin receptor SHC signaling
Drugs		Sargramostim	KB002
Diseases
GWAS		Crohn's disease ( 22412388) Glucose homeostasis traits ( 25524916)	Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908 23128233) Rheumatoid arthritis ( 30423114 22446963 24390342) Ulcerative colitis ( 28067908)
Interacting Genes		7 interacting genes: AGT AKT1 CHD3 CSF2 PAPPA PRKCZ RBM48	8 interacting genes: CSF2RA CSF2RB FBN2 IL3RA KITLG MEOX2 PRG2 SDC2
Entrez ID		5553	1437
HPRD ID		09283	00734
Ensembl ID		ENSG00000186652	ENSG00000164400
Uniprot IDs		P13727	P04141
PDB IDs		1H8U 2BRS 4QXX	1CSG 2GMF 4NKQ 4RS1 5C7X 5D70 5D71 5D72 6BFQ 6BFS
Enriched GO Terms of Interacting Partners?
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