NUDT15 and SRD5A3

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		NUDT15	SRD5A3
Description		nudix hydrolase 15	steroid 5 alpha-reductase 3
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding 8-oxo-7,8-dihydroguanosine Triphosphate Pyrophosphatase Activity Nucleoside-diphosphatase Activity NADH Pyrophosphatase Activity 8-oxo-7,8-dihydrodeoxyguanosine Triphosphate Pyrophosphatase Activity Metal Ion Binding Nucleoside-triphosphate Diphosphatase Activity	3-oxo-5-alpha-steroid 4-dehydrogenase Activity Oxidoreductase Activity, Acting On The CH-CH Group Of Donors, NAD Or NADP As Acceptor Cholestenone 5-alpha-reductase Activity Polyprenol Reductase Activity
	Biological Process	Mitotic Cell Cycle Response To Reactive Oxygen Species Purine Nucleotide Catabolic Process DGTP Catabolic Process Nucleobase-containing Small Molecule Catabolic Process DNA Protection Exogenous Drug Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Nucleoside Phosphate Catabolic Process	Dolichol-linked Oligosaccharide Biosynthetic Process Dolichyl Diphosphate Biosynthetic Process Androgen Biosynthetic Process Polyprenol Catabolic Process Dolichol Metabolic Process Dolichol Biosynthetic Process Oxidation-reduction Process
Pathways		Phosphate bond hydrolysis by NUDT proteins	Androgen biosynthesis Synthesis of Dolichyl-phosphate Defective SRD5A3 causes SRD5A3-CDG (CDG-1q) and KHRZ
Drugs			Spironolactone
Diseases
GWAS		Estimated glomerular filtration rate ( 31015462) Thiopurine-induced acute severe leukopenia in inflammatory bowel disease ( 29923122) Thiopurine-induced alopecia in inflammatory bowel disease ( 29923122) Thiopurine-induced early leukopenia in Crohn's disease ( 25108385) Thiopurine-induced leukopenia in inflammatory bowel disease ( 27558924 29923122) Thiopurine-induced severe alopecia in inflammatory bowel disease ( 29923122) Thiopurine-induced severe leukopenia in inflammatory bowel disease ( 29923122)	Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		1 interacting genes: SRD5A3	2 interacting genes: ADK NUDT15
Entrez ID		55270	79644
HPRD ID		14848	07825
Ensembl ID		ENSG00000136159	ENSG00000128039
Uniprot IDs		Q9NV35	Q9H8P0
PDB IDs		5BON 5LPG
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?