PPP2R1B and CEP43

Number of citations of the paper that reports this interaction (PubMedID 17540176)
91

Data Source:
HPRD (in vivo)

		PPP2R1B	CEP43
Description		protein phosphatase 2 scaffold subunit Abeta	centrosomal protein 43
Image		No pdb structure
GO Annotations	Cellular Component	Protein Phosphatase Type 2A Complex Cytoplasm Protein Serine/threonine Phosphatase Complex Membrane Raft Extracellular Exosome	Nucleus Centrosome Centriole Cytosol Cell Projection Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Serine/threonine Phosphatase Activity Protein Binding Protein Phosphatase Regulator Activity	Protein Binding Protein Kinase Binding Protein Tyrosine Kinase Inhibitor Activity Protein Homodimerization Activity
	Biological Process	Protein Dephosphorylation Regulation Of Phosphoprotein Phosphatase Activity Apoptotic Process Involved In Morphogenesis Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Protein Kinase Activity Positive Regulation Of Cell Proliferation Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Cell Growth Positive Regulation Of Cell Migration Microtubule Anchoring Negative Regulation Of Protein Tyrosine Kinase Activity Ciliary Basal Body-plasma Membrane Docking
Pathways		Inhibition of replication initiation of damaged DNA by RB1/E2F1 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Integration of energy metabolism PP2A-mediated dephosphorylation of key metabolic factors DARPP-32 events Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade ERK/MAPK targets ERKs are inactivated MASTL Facilitates Mitotic Progression Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion CTLA4 inhibitory signaling Platelet sensitization by LDL Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Misspliced GSK3beta mutants stabilize beta-catenin S33 mutants of beta-catenin aren't phosphorylated S37 mutants of beta-catenin aren't phosphorylated S45 mutants of beta-catenin aren't phosphorylated T41 mutants of beta-catenin aren't phosphorylated APC truncation mutants have impaired AXIN binding AXIN missense mutants destabilize the destruction complex Truncations of AMER1 destabilize the destruction complex RHO GTPases Activate Formins RAF activation Negative regulation of MAPK pathway Regulation of TP53 Degradation PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Mitotic Prometaphase Cyclin D associated events in G1 Cyclin A/B1/B2 associated events during G2/M transition Regulation of glycolysis by fructose 2,6-bisphosphate metabolism EML4 and NUDC in mitotic spindle formation	Signaling by cytosolic FGFR1 fusion mutants Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane Signaling by FGFR1 in disease AURKA Activation by TPX2
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29785011) Asthma ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011)
Interacting Genes		42 interacting genes: AKAP9 ANXA5 BHLHE41 BSG CDK1 CDK4 CEP43 CFTR CLOCK CRY1 CRY2 CSNK2B DELEC1 EEF2 FBXW11 HDAC1 HSPD1 HYOU1 JAK2 MCM3 PARK7 PPP2CA PPP2R2A PPP2R3B PPP2R5C PPP2R5D PPP2R5E PRDX1 PRDX2 RAB11A RAB18 RAB7A RALA RELA RORC SET SGO1 SGO2 STRN STRN3 TIMM8B UNC5B	8 interacting genes: LINC01558 NAGK PPP2R1B RNASET2 S100A6 TBP TCP10L3 VASP
Entrez ID		5519	11116
HPRD ID		04384	10392
Ensembl ID		ENSG00000137713	ENSG00000213066
Uniprot IDs		P30154	A0A087WV25 B4DH64 O95684
PDB IDs			2D68
Enriched GO Terms of Interacting Partners?
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