PPP2CB and TIPRL

Number of citations of the paper that reports this interaction (PubMedID 26344197)
117

Data Source:
BioGRID (biochemical, affinity chromatography technology, pull down)

		PPP2CB	TIPRL
Description		protein phosphatase 2 catalytic subunit beta	TOR signaling pathway regulator
Image		No pdb structure
GO Annotations	Cellular Component	Protein Phosphatase Type 2A Complex Chromosome, Centromeric Region Spindle Pole Nucleus Cytosol	Cytosol
	Molecular Function	Protein Serine/threonine Phosphatase Activity Protein Binding Protein C-terminus Binding Metal Ion Binding Tau Protein Binding	Protein Binding
	Biological Process	Protein Dephosphorylation Apoptotic Mitochondrial Changes Response To Lead Ion Regulation Of Gene Expression Response To Endoplasmic Reticulum Stress Peptidyl-threonine Dephosphorylation Response To Hydrogen Peroxide Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Ras Protein Signal Transduction Peptidyl-serine Dephosphorylation Positive Regulation Of Microtubule Binding	DNA Damage Checkpoint Signal Transduction TOR Signaling Negative Regulation Of Phosphoprotein Phosphatase Activity Regulation Of Phosphoprotein Phosphatase Activity
Pathways		Inhibition of replication initiation of damaged DNA by RB1/E2F1 Spry regulation of FGF signaling Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Integration of energy metabolism PP2A-mediated dephosphorylation of key metabolic factors DARPP-32 events Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade ERK/MAPK targets ERKs are inactivated MASTL Facilitates Mitotic Progression Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion CTLA4 inhibitory signaling Platelet sensitization by LDL Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Misspliced GSK3beta mutants stabilize beta-catenin S33 mutants of beta-catenin aren't phosphorylated S37 mutants of beta-catenin aren't phosphorylated S45 mutants of beta-catenin aren't phosphorylated T41 mutants of beta-catenin aren't phosphorylated APC truncation mutants have impaired AXIN binding AXIN missense mutants destabilize the destruction complex Truncations of AMER1 destabilize the destruction complex RHO GTPases Activate Formins RAF activation Negative regulation of MAPK pathway Regulation of TP53 Degradation PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Mitotic Prometaphase Cyclin D associated events in G1 Cyclin A/B1/B2 associated events during G2/M transition Regulation of glycolysis by fructose 2,6-bisphosphate metabolism EML4 and NUDC in mitotic spindle formation
Drugs		Vitamin E
Diseases
GWAS		Daytime sleep phenotypes ( 27126917)
Interacting Genes		28 interacting genes: ACP5 AXIN1 BHLHE41 C22orf39 DOCK7 GAD1 GSTA1 HK3 LCMT1 MAK MAPT MID1 PACS1 PLAT PLXNA3 PRKCB RAF1 RELA RPLP1 SGO1 TAB1 TAB2 TCTEX1D2 TIPRL TLX1 TRMT61B ZFP28 ZNF775	4 interacting genes: APP PPP2CB PPP4C PPP6C
Entrez ID		5516	261726
HPRD ID		01487	14608
Ensembl ID		ENSG00000104695	ENSG00000143155
Uniprot IDs		A0A140VJS0 P62714	O75663
PDB IDs			5D9G
Enriched GO Terms of Interacting Partners?
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