PPBP and PMAIP1

Number of citations of the paper that reports this interaction (PubMedID 16169070)
820

Data Source:
HPRD (two hybrid)

		PPBP	PMAIP1
Description		pro-platelet basic protein	phorbol-12-myristate-13-acetate-induced protein 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Platelet Alpha Granule Lumen Tertiary Granule Lumen	Nucleus Mitochondrion Mitochondrial Outer Membrane Cytosol
	Molecular Function	Glucose Transmembrane Transporter Activity Protein Binding Chemokine Activity Growth Factor Activity CXCR Chemokine Receptor Binding	Protein Binding
	Biological Process	Platelet Degranulation Inflammatory Response Immune Response G Protein-coupled Receptor Signaling Pathway Neutrophil Chemotaxis Leukocyte Chemotaxis Defense Response To Bacterium Neutrophil Degranulation Positive Regulation Of Cell Division Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Glucose Transmembrane Transport	Release Of Cytochrome C From Mitochondria Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Response To DNA Damage Stimulus Proteasomal Protein Catabolic Process Positive Regulation Of Glucose Metabolic Process Negative Regulation Of Mitochondrial Membrane Potential Cellular Response To Glucose Starvation Regulation Of Apoptotic Process T Cell Homeostasis Positive Regulation Of Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Response To DsRNA Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Mitochondrial Membrane Permeability Defense Response To Virus Cellular Response To Hypoxia Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Reactive Oxygen Species Metabolic Process Positive Regulation Of Release Of Cytochrome C From Mitochondria Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Platelet degranulation Chemokine receptors bind chemokines G alpha (i) signalling events Neutrophil degranulation	Activation of NOXA and translocation to mitochondria BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
Drugs		Ethanesulfonic Acid Copper
Diseases
GWAS		Metabolite levels ( 22916037)	Body mass index ( 26426971 23669352 28892062) Body mass index (age>50) ( 26426971) Body mass index x age interaction ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Chronic lymphocytic leukemia ( 26956414 23770605) Coronary artery disease ( 26343387) HDL cholesterol levels ( 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Height ( 31562340) Metabolic syndrome ( 20694148) Metabolite levels ( 23823483) Regular attendance at a pub or social club ( 29970889) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)
Interacting Genes		20 interacting genes: CELF1 CMTM6 COPG1 COPS7A COX17 CTSG CXCR1 CXCR2 DMWD EFNA1 MAPK6 MOB3B NDUFB11 NR4A1 PLEKHJ1 PMAIP1 RAB10 RPS27 SCFD1 STRN4	9 interacting genes: BAX BCL2 BCL2A1 BCL2L1 GSK3B MCL1 PPBP RNF7 ZBTB16
Entrez ID		5473	5366
HPRD ID		07171	12002
Ensembl ID		ENSG00000163736	ENSG00000141682
Uniprot IDs		P02775	A0A0S2Z490 Q13794
PDB IDs		1F9P 1NAP 1TVX	3MQP
Enriched GO Terms of Interacting Partners?
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