UGT1A1 and UGDH

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		UGT1A1	UGDH
Description		UDP glucuronosyltransferase family 1 member A1	UDP-glucose 6-dehydrogenase
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Plasma Membrane Endoplasmic Reticulum Chaperone Complex Cytochrome Complex	Nucleus Nucleoplasm Cytosol Extracellular Exosome
	Molecular Function	Retinoic Acid Binding Enzyme Inhibitor Activity Steroid Binding Glucuronosyltransferase Activity Enzyme Binding Protein Homodimerization Activity	UDP-glucose 6-dehydrogenase Activity NAD Binding
	Biological Process	Liver Development Bilirubin Conjugation Acute-phase Response Response To Nutrient Steroid Metabolic Process Estrogen Metabolic Process Drug Metabolic Process Animal Organ Regeneration Response To Lipopolysaccharide Heme Catabolic Process Retinoic Acid Metabolic Process Response To Starvation Negative Regulation Of Catalytic Activity Negative Regulation Of Steroid Metabolic Process Heterocycle Metabolic Process Flavone Metabolic Process Cellular Glucuronidation Flavonoid Glucuronidation Xenobiotic Glucuronidation Biphenyl Catabolic Process Cellular Response To Ethanol Cellular Response To Glucocorticoid Stimulus Cellular Response To Estradiol Stimulus	Gastrulation With Mouth Forming Second Carbohydrate Metabolic Process Glycosaminoglycan Biosynthetic Process UDP-glucuronate Biosynthetic Process Heparan Sulfate Proteoglycan Biosynthetic Process Chondroitin Sulfate Biosynthetic Process Protein Hexamerization Oxidation-reduction Process
Pathways		Glucuronidation Defective UGT1A1 causes hyperbilirubinemia	Formation of the active cofactor, UDP-glucuronate
Drugs			NADH Copper
Diseases		Hyperbilirubinemia; Crigler-Najjar syndrome, type I (CN1); Crigler-Najjar syndrome, type II (CN2); Gilbert Syndrome; Dubin-Johnson syndrome (DJS)
GWAS		Bilirubin levels ( 22085899 19419973 23371916 20639394 19414484) Bilirubin levels in extreme obesity ( 25246029) Blood metabolite levels ( 24816252) Cholelithiasis-related traits in sickle cell anemia ( 22558097) Cholesterol, total ( 24097068) Circulating cell-free DNA ( 22511988) Hair greying ( 26926045) LDL cholesterol ( 24097068) LDL cholesterol levels ( 28334899) Serum bilirubin levels in metabolic syndrome ( 30621171) Serum metabolite levels ( 23093944) Total bilirubin levels ( 29403010) Total bilirubin levels in HIV-1 infection ( 25884002)
Interacting Genes		3 interacting genes: COPZ1 SEC23B UGDH	3 interacting genes: AK5 RAD51 UGT1A1
Entrez ID		54658	7358
HPRD ID		08933	04535
Ensembl ID		ENSG00000241635	ENSG00000109814
Uniprot IDs		P22309 Q5DT03	O60701
PDB IDs			2Q3E 2QG4 3ITK 3KHU 3PRJ 3PTZ 3TDK 3TF5 4EDF 4RJT 5TJH 5VR8 5W4X 6C4J 6C4K 6C58 6C5A 6C5Z
Enriched GO Terms of Interacting Partners?
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