LZTFL1 and FZD5

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		LZTFL1	FZD5
Description		leucine zipper transcription factor like 1	frizzled class receptor 5
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol	Golgi Membrane Plasma Membrane Integral Component Of Plasma Membrane Bicellular Tight Junction Cell Surface Integral Component Of Membrane Axon Dendrite Clathrin-coated Endocytic Vesicle Membrane Early Endosome Membrane Perikaryon Synapse Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Identical Protein Binding Protein-containing Complex Binding	Amyloid-beta Binding G Protein-coupled Receptor Activity Protein Binding Lipid Binding Wnt-protein Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Wnt-activated Receptor Activity Protein-containing Complex Binding
	Biological Process	Negative Regulation Of Protein Localization To Cilium Negative Regulation Of Protein Localization To Ciliary Membrane	Embryonic Axis Specification Angiogenesis Positive Regulation Of T Cell Cytokine Production G Protein-coupled Receptor Signaling Pathway Wnt Signaling Pathway, Calcium Modulating Pathway Synapse Assembly Negative Regulation Of Cell Proliferation Anterior/posterior Axis Specification, Embryo Neuron Differentiation Post-embryonic Camera-type Eye Development Positive Regulation Of Interferon-gamma Production T Cell Differentiation In Thymus Non-canonical Wnt Signaling Pathway Positive Regulation Of JUN Kinase Activity Positive Regulation Of Transcription By RNA Polymerase II Cell Maturation Embryonic Camera-type Eye Morphogenesis Positive Regulation Of Interleukin-1 Beta Secretion Spemann Organizer Formation Canonical Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Apoptotic Process Involved In Morphogenesis Branching Involved In Labyrinthine Layer Morphogenesis Syncytiotrophoblast Cell Differentiation Involved In Labyrinthine Layer Development Labyrinthine Layer Blood Vessel Development Chorionic Trophoblast Cell Differentiation Cellular Response To Molecule Of Bacterial Origin Regulation Of Chorionic Trophoblast Cell Proliferation Regulation Of Autophagy Of Mitochondrion Positive Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Tumor Necrosis Factor Secretion Beta-catenin Destruction Complex Disassembly Regulation Of Bicellular Tight Junction Assembly
Pathways		BBSome-mediated cargo-targeting to cilium	Class B/2 (Secretin family receptors) Ca2+ pathway Ca2+ pathway Asymmetric localization of PCP proteins Disassembly of the destruction complex and recruitment of AXIN to the membrane Regulation of FZD by ubiquitination WNT5A-dependent internalization of FZD2, FZD5 and ROR2 RNF mutants show enhanced WNT signaling and proliferation
Drugs
Diseases
GWAS		Acne (severe) ( 24927181) Methadone dose in opioid dependence ( 28115739) Multiple sclerosis ( 31604244)
Interacting Genes		3 interacting genes: FZD5 NTAQ1 SDCBP	11 interacting genes: ABI3BP GOPC GSK3B LRP6 LZTFL1 RGS2 ROR2 RPS6KA6 UBTD1 WNT5A WNT7A
Entrez ID		54585	7855
HPRD ID		07586	03427
Ensembl ID		ENSG00000163818	ENSG00000163251
Uniprot IDs		Q9NQ48	Q13467
PDB IDs			5URY 5URZ 6O39
Enriched GO Terms of Interacting Partners?
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