ETAA1 and MOGS

		ETAA1	MOGS
Description		ETAA1 activator of ATR kinase	mannosyl-oligosaccharide glucosidase
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nuclear Replication Fork	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane Extracellular Exosome
	Molecular Function	Protein Binding Protein Serine/threonine Kinase Activator Activity	Mannosyl-oligosaccharide Glucosidase Activity Glucosidase Activity
	Biological Process	DNA Repair Cellular Response To DNA Damage Stimulus Replication Fork Processing Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of DNA Damage Checkpoint	Protein Folding Protein N-linked Glycosylation Oligosaccharide Metabolic Process
Pathways			Defective MOGS causes MOGS-CDG (CDG-2b) N-glycan trimming in the ER and Calnexin/Calreticulin cycle
Drugs
Diseases			Congenital disorders of glycosylation (CDG) type II
GWAS		Endometriosis ( 28537267) Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Male-pattern baldness ( 27182965) Milk allergy ( 25710614) Pancreatic cancer ( 26098869) Periodontitis (CDC/AAP) ( 24024966) Photic sneeze reflex ( 27182965) Systolic blood pressure response to hydrochlorothiazide in hypertension ( 27802415) Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia ( 25710658) Waist-hip ratio ( 23966867) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for body mass index ( 28430825 28448500)
Interacting Genes		1 interacting genes: MOGS	9 interacting genes: C1D CHGB ETAA1 EXOC6B MXD1 PCBP1 RAB11FIP5 REL VPS54
Entrez ID		54465	7841
HPRD ID		13282	03214
Ensembl ID		ENSG00000143971	ENSG00000115275
Uniprot IDs		Q9NY74	A0A384MDR6 Q13724 Q58F09
PDB IDs
Enriched GO Terms of Interacting Partners?
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