PON2 and HTR2A

Number of citations of the paper that reports this interaction (PubMedID 16537434)
17

Data Source:
HPRD (two hybrid)

		PON2	HTR2A
Description		paraoxonase 2	5-hydroxytryptamine receptor 2A
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Mitochondrion Lysosome Plasma Membrane	Cell Cytosol Plasma Membrane Integral Component Of Plasma Membrane Caveola Cell Junction Axon Dendrite Cytoplasmic Vesicle Neuronal Cell Body Dendritic Shaft Cell Body Fiber Glutamatergic Synapse Integral Component Of Postsynaptic Membrane Integral Component Of Presynaptic Membrane
	Molecular Function	Arylesterase Activity Identical Protein Binding Metal Ion Binding Acyl-L-homoserine-lactone Lactonohydrolase Activity	Virus Receptor Activity G-protein Alpha-subunit Binding G Protein-coupled Receptor Activity G Protein-coupled Serotonin Receptor Activity Protein Binding Drug Binding Neurotransmitter Receptor Activity Identical Protein Binding Protein-containing Complex Binding Serotonin Binding 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine Binding
	Biological Process	Response To Oxidative Stress Response To Toxic Substance Lipoxygenase Pathway Aromatic Compound Catabolic Process	Temperature Homeostasis Cellular Calcium Ion Homeostasis G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Activation Of Phospholipase C Activity Phospholipase C-activating Serotonin Receptor Signaling Pathway Serotonin Receptor Signaling Pathway Chemical Synaptic Transmission Aging Memory Cell Death Positive Regulation Of Cell Proliferation Positive Regulation Of Phosphatidylinositol Biosynthetic Process Regulation Of Dopamine Secretion Phosphatidylinositol 3-kinase Signaling Artery Smooth Muscle Contraction Urinary Bladder Smooth Muscle Contraction Sleep Response To Drug Negative Regulation Of Potassium Ion Transport Positive Regulation Of MAP Kinase Activity Protein Localization To Cytoskeleton Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Glycolytic Process Positive Regulation Of Vasoconstriction Viral Entry Into Host Cell Behavioral Response To Cocaine Positive Regulation Of Peptidyl-tyrosine Phosphorylation Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain Release Of Sequestered Calcium Ion Into Cytosol Negative Regulation Of Synaptic Transmission, Glutamatergic Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Synaptic Vesicle Exocytosis
Pathways		Synthesis of 5-eicosatetraenoic acids	Serotonin receptors G alpha (q) signalling events
Drugs			Ziprasidone Methysergide Cabergoline Ropinirole Amitriptyline Olanzapine Clozapine Mirtazapine Loxapine Remoxipride Pramipexole Promazine Cyproheptadine Imipramine Chlorpromazine Chlorpromazine Haloperidol Nortriptyline Amoxapine Fenfluramine Lisuride Cisapride Fluphenazine Trazodone Thioridazine Ergotamine Apomorphine Paroxetine Trimipramine Risperidone Epinastine Propiomazine Minaprine Donepezil Flupentixol Cyclobenzaprine Mesoridazine Maprotiline Ergoloid mesylate Promethazine Tegaserod Doxepin Nefazodone Desipramine Pergolide Bromocriptine Ketamine Quetiapine Aripiprazole Chlorprothixene Clomipramine Paliperidone Yohimbine Methotrimeprazine MMDA Midomafetamine Dimethyltryptamine 4-Bromo-2,5-dimethoxyphenethylamine Acepromazine Molindone Pipotiazine Thioproperazine Thiothixene Zuclopenthixol Aniracetam Fluspirilene Flibanserin Iloperidone HY10275 APD791 Pimavanserin Epicept NP-1 BL-1020 Cariprazine Lumateperone Sertindole Mianserin Asenapine Amisulpride Deramciclane Esmirtazapine Cinitapride Lurasidone Perospirone Amperozide Butriptyline Brexpiprazole Dosulepin Etoperidone Setiptiline Sarpogrelate Ketanserin Nelotanserin Ritanserin Tiapride
Diseases
GWAS		Yu-Zhi constitution type in type 2 diabetes ( 26169365)	Blood protein levels ( 28240269) Cardiac hypertrophy ( 21348951) Parkinson disease and lewy body pathology ( 25663231) Serum 25-Hydroxyvitamin D levels ( 29325163) SjÃ¶gren's syndrome ( 28076899) Subcutaneous adipose tissue ( 22589738)
Interacting Genes		2 interacting genes: GRB2 HTR2A	18 interacting genes: ANKS1B ARF1 ARF6 DLG4 EIF3F GLUL GNA11 GNAI1 GNAQ JAK2 MAP1A MRPL28 NDUFB10 NME3 NTRK3 PON2 PPP5C RPS6KA3
Entrez ID		5445	3356
HPRD ID		03903	01638
Ensembl ID		ENSG00000105854	ENSG00000102468
Uniprot IDs		Q15165	P28223
PDB IDs			6A93 6A94
Enriched GO Terms of Interacting Partners?
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