TERF2IP and IL1RN

Number of citations of the paper that reports this interaction (PubMedID 21044950)
41

Data Source:
BioGRID (two hybrid)

		TERF2IP	IL1RN
Description		TERF2 interacting protein	interleukin 1 receptor antagonist
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GO Annotations	Cellular Component	Nuclear Chromosome Chromosome, Telomeric Region Nuclear Telomere Cap Complex Nuclear Chromosome, Telomeric Region Nucleus Nuclear Envelope Nucleoplasm Cytoplasm Cytosol Nuclear Body Mre11 Complex Shelterin Complex	Extracellular Space Cytoplasm Plasma Membrane Extracellular Exosome
	Molecular Function	DNA Binding Protein Binding Phosphatase Binding Telomeric DNA Binding G-rich Strand Telomeric DNA Binding	Cytokine Activity Interleukin-1, Type I Receptor Binding Interleukin-1, Type II Receptor Binding Interleukin-1 Receptor Antagonist Activity Protein Binding Interleukin-1 Type I Receptor Antagonist Activity Interleukin-1 Type II Receptor Antagonist Activity
	Biological Process	Telomere Maintenance Negative Regulation Of Protein Phosphorylation Regulation Of Transcription, DNA-templated Telomere Maintenance Via Telomerase Regulation Of Double-strand Break Repair Via Homologous Recombination Telomere Maintenance Via Telomere Lengthening Telomere Capping Protection From Non-homologous End Joining At Telomere Regulation Of Telomere Maintenance Negative Regulation Of Telomere Maintenance Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of DNA Recombination At Telomere Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Localization To Chromosome, Telomeric Region Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Protein Acetylation	Inflammatory Response To Antigenic Stimulus Lipid Metabolic Process Inflammatory Response Immune Response Cytokine-mediated Signaling Pathway Insulin Secretion Negative Regulation Of Heterotypic Cell-cell Adhesion Response To Glucocorticoid Interleukin-1-mediated Signaling Pathway Negative Regulation Of Interleukin-1-mediated Signaling Pathway
Pathways		Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Telomere Extension By Telomerase DNA Damage/Telomere Stress Induced Senescence	Interleukin-10 signaling Interleukin-1 signaling
Drugs			Rilonacept
Diseases			Graft-versus-host disease
GWAS		Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Smoking status (ever vs never smokers) ( 30643258) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)	Blood protein levels ( 30072576 29875488) C-reactive protein ( 22939635) Dysmenorrheic pain ( 27454463) Fibrinogen ( 23969696) Fibrinogen levels ( 28107422) Granulocyte count ( 27863252) Lymphocyte percentage of white cells ( 27863252) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252) Neutrophil percentage of white cells ( 27863252) Obesity-related traits ( 23251661) Protein quantitative trait loci ( 18464913) Stroke ( 26089329) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252)
Interacting Genes		127 interacting genes: ADA AIMP2 AK1 AKR1A1 AKR1B10 AKR7A3 AKT1 ANXA5 ANXA8L1 AP2B1 APEX1 ARPP21 BABAM1 BANP BCL7B C1orf174 C9orf78 CALML3 CHMP2B COTL1 CPNE2 CPNE3 CRK CRYBB1 CRYGS CTBP1 DBNL DDX23 DDX24 DDX39A DHX38 DNMT3A DPP3 ENAH EPAS1 EPS8L1 FABP2 FAM122A GAGE5 GAMT GNMT GPAA1 GPKOW H1-1 H2AC16 H4C2 HAAO HAGH HDGFL3 HMGB1 HMGB3 HMGN3 HMGN4 HNRNPK IDO1 IL1RN LANCL2 LGALSL MAGOHB MCM2 MDH1 MPG MRTO4 MT1X MT3 NAIF1 NASP NOL3 NUDT14 NUDT18 NUMA1 NXNL1 OCM2 OGFR PACSIN2 PACSIN3 PAFAH1B3 PCNP PCP4 PEA15 PGLS PGM1 PML PNMT POLD1 PPM1G PPP1R2 PPP6R3 PRDX6 PRX PTMA RABIF RAD50 RASSF5 RBBP9 RECQL4 RGMA RIF1 RPAP1 RPP25 S100P SBDS SCLY SCRN2 SET SMARCC2 SNCG SP100 TALDO1 TBC1D10A TBCA TERF2 TMSB10 TMSB4Y TOR1AIP1 TSSC4 TWF2 UCHL1 VGLL4 WDR5 WIPI2 XAGE2 XPO1 XRCC5 XRCC6 ZNF146 ZNF414	6 interacting genes: COPS3 COPS4 IL1R1 IL1R2 POT1 TERF2IP
Entrez ID		54386	3557
HPRD ID		05452	00978
Ensembl ID		ENSG00000166848	ENSG00000136689
Uniprot IDs		Q9NYB0	A0A024R528 P18510
PDB IDs		1FEX 3K6G 4RQI	1ILR 1ILT 1IRA 1IRP 1ITN 2IRT
Enriched GO Terms of Interacting Partners?
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