PIK3CD and IL4

Number of citations of the paper that reports this interaction (PubMedID 9113989)
134

Data Source:
HPRD (in vivo)

		PIK3CD	IL4
Description		phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	interleukin 4
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GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Phosphatidylinositol 3-kinase Complex Membrane Mast Cell Granule	Extracellular Region Extracellular Space
	Molecular Function	Protein Binding ATP Binding Kinase Activity 1-phosphatidylinositol-3-kinase Activity Phosphatidylinositol 3-kinase Activity 1-phosphatidylinositol-4-phosphate 3-kinase Activity Phosphatidylinositol-4,5-bisphosphate 3-kinase Activity Phosphatidylinositol Kinase Activity Phosphatidylinositol-3,4-bisphosphate 5-kinase Activity	Cytokine Activity Interleukin-4 Receptor Binding Protein Binding Growth Factor Activity
	Biological Process	Natural Killer Cell Differentiation Cytokine Production Adaptive Immune Response Mast Cell Chemotaxis Respiratory Burst Involved In Defense Response Protein Phosphorylation Phosphatidylinositol Biosynthetic Process Inflammatory Response Signal Transduction Axon Guidance Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression T Cell Chemotaxis Phosphatidylinositol 3-kinase Signaling Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Phosphorylation Cell Migration Cytokine-mediated Signaling Pathway Natural Killer Cell Activation T Cell Differentiation Positive Regulation Of Cell Migration Neutrophil Chemotaxis Positive Regulation Of Neutrophil Apoptotic Process Natural Killer Cell Chemotaxis B Cell Chemotaxis Phosphatidylinositol-3-phosphate Biosynthetic Process T Cell Activation B Cell Activation Mast Cell Degranulation Innate Immune Response Phosphatidylinositol Phosphorylation Phosphatidylinositol-mediated Signaling T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway Positive Regulation Of Protein Kinase B Signaling Mast Cell Differentiation Neutrophil Extravasation	Immune Response Cholesterol Metabolic Process Positive Regulation Of Gene Expression Negative Regulation Of Epithelial Cell Migration Positive Regulation Of Macroautophagy Cytokine-mediated Signaling Pathway B Cell Differentiation Positive Regulation Of B Cell Proliferation Positive Regulation Of Interleukin-13 Production T-helper 2 Cell Cytokine Production Type 2 Immune Response Positive Regulation Of T Cell Proliferation T Cell Activation Regulation Of Phosphorylation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Tumor Necrosis Factor Biosynthetic Process Activation Of Janus Kinase Activity Myeloid Dendritic Cell Differentiation Negative Regulation Of Apoptotic Process Connective Tissue Growth Factor Biosynthetic Process Regulation Of Isotype Switching Positive Regulation Of MHC Class II Biosynthetic Process Positive Regulation Of T Cell Differentiation Negative Regulation Of Osteoclast Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Isotype Switching To IgE Isotypes Positive Regulation Of Isotype Switching To IgG Isotypes Regulation Of Immune Response Dendritic Cell Differentiation Positive Regulation Of Cold-induced Thermogenesis Neuroinflammatory Response Negative Regulation Of Neuroinflammatory Response Positive Regulation Of Amyloid-beta Clearance Positive Regulation Of Cellular Respiration Negative Regulation Of Complement-dependent Cytotoxicity Negative Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of ATP Biosynthetic Process
Pathways		PIP3 activates AKT signaling Synthesis of PIPs at the plasma membrane Constitutive Signaling by Aberrant PI3K in Cancer Interleukin-3, Interleukin-5 and GM-CSF signaling PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling RET signaling Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Interleukin receptor SHC signaling Regulation of signaling by CBL Regulation of signaling by CBL Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	Interleukin-4 and Interleukin-13 signaling Interleukin-18 signaling
Drugs		Caffeine XL765 2-((9H-PURIN-6-YLTHIO)METHYL)-5-CHLORO-3-(2-METHOXYPHENYL)QUINAZOLIN-4(3H)-ONE Copanlisib
Diseases			Asthma
GWAS		Diisocyanate-induced asthma ( 25918132) Irritable bowel syndrome ( 29626450) Monocyte count ( 27863252) Systemising ( 31508503) Testicular germ cell tumor ( 28604728)	Asthma ( 31619474 29273806) Asthma (childhood onset) ( 31036433 29273806) Asthma or allergic disease (pleiotropy) ( 29785011) Atopic dermatitis ( 25574825) Atopic march ( 26542096) Inflammatory bowel disease ( 23128233) Psoriasis ( 25574825 23143594) Psoriasis vulgaris ( 26626624)
Interacting Genes		14 interacting genes: ASCC2 ERAS HRAS IL3 IL4 IRS2 KITLG MCRIP2 PIK3CG PIK3R1 PIK3R2 RALY TAGLN TNPO2	7 interacting genes: A2M CD53 FBXO7 IL13RA2 IL2RG IL4R PIK3CD
Entrez ID		5293	3565
HPRD ID		04161	00989
Ensembl ID		ENSG00000171608	ENSG00000113520
Uniprot IDs		A0A2K8FKV1 O00329	D4HNR6 P05112 Q5FC01
PDB IDs		5DXU 5M6U 5T8F 5UBT 5VLR 6G6W 6PYR 6PYU	1BBN 1BCN 1CYL 1HIJ 1HIK 1HZI 1IAR 1ILL 1ITE 1ITI 1ITL 1ITM 1RCB 2B8U 2B8X 2B8Y 2B8Z 2B90 2B91 2CYK 2D48 2INT 3BPL 3BPN 3QB7 4YDY 5FHX 6OEL
Enriched GO Terms of Interacting Partners?
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