PHB and COX6C

Number of citations of the paper that reports this interaction (PubMedID 20195357)
30

Data Source:
BioGRID (biochemical, pull down)

		PHB	COX6C
Description		prohibitin	cytochrome c oxidase subunit 6C
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Inner Membrane Early Endosome Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Membrane Extracellular Exosome	Mitochondrion Mitochondrial Inner Membrane Integral Component Of Membrane
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Complement Component C3a Binding Complement Component C3b Binding Protein Binding Protein C-terminus Binding Enzyme Binding Proteinase Activated Receptor Binding Histone Deacetylase Binding Transcription Regulatory Region DNA Binding	Cytochrome-c Oxidase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Osteoblast Differentiation Regulation Of Transcription, DNA-templated Mitochondrial Calcium Ion Transmembrane Transport Mitochondrion Organization Signal Transduction Negative Regulation Of Cell Proliferation Positive Regulation Of Gene Expression Positive Regulation Of Cell Death Negative Regulation Of Transcription By Competitive Promoter Binding Histone Deacetylation Negative Regulation Of Cell Growth Negative Regulation Of Protein Catabolic Process Regulation Of Apoptotic Process Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Complement Activation Protein Stabilization Progesterone Receptor Signaling Pathway Negative Regulation Of Androgen Receptor Signaling Pathway Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Interleukin-6 DNA Biosynthetic Process Negative Regulation Of Glucocorticoid Receptor Signaling Pathway	Generation Of Precursor Metabolites And Energy Mitochondrial Electron Transport, Cytochrome C To Oxygen Proton Transmembrane Transport
Pathways		RAF activation Signaling by moderate kinase activity BRAF mutants Paradoxical activation of RAF signaling by kinase inactive BRAF Processing of SMDT1 Signaling downstream of RAS mutants	TP53 Regulates Metabolic Genes Respiratory electron transport
Drugs			Cholic Acid N-Formylmethionine
Diseases
GWAS		Asthma ( 30929738 29273806) Asthma (adult onset) ( 30929738) Asthma (childhood onset) ( 31036433 30929738) Cancer ( 29299148) Coronary artery disease ( 29212778) Diastolic blood pressure ( 19430483 27841878) Lower body strength ( 27325353) Metabolite levels ( 23823483) Prostate cancer ( 23535732) Restricted and repetitive behaviours in autism spectrum disorder ( 28533516) Systolic blood pressure ( 27841878 30578418)	Glucose homeostasis traits ( 25524916)
Interacting Genes		23 interacting genes: ANXA2 BCAS3 CASC3 CCL5 COX6C E2F1 ESR1 HDAC1 LONRF3 MAP3K10 MCM2 NCOR1 RAF1 RB1 RBL1 RBL2 SIN3A SMARCA2 SMARCA4 ST14 SUMO4 TP53 XPO1	3 interacting genes: PHB PTN RCHY1
Entrez ID		5245	1345
HPRD ID		01454	00494
Ensembl ID		ENSG00000167085	ENSG00000164919
Uniprot IDs		A8K401 P35232 Q53FV0	A0A024R9B7 P09669
PDB IDs		1LU7	5Z62
Enriched GO Terms of Interacting Partners?
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