PFKFB2 and PRKAA2

Number of citations of the paper that reports this interaction (PubMedID 12853467)
31

Data Source:
HPRD (in vitro)

		PFKFB2	PRKAA2
Description		6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2	protein kinase AMP-activated catalytic subunit alpha 2
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GO Annotations	Cellular Component	Nucleoplasm Cytosol	Cell Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Cytoplasmic Stress Granule Nuclear Speck Axon Dendrite Neuronal Cell Body
	Molecular Function	6-phosphofructo-2-kinase Activity Fructose-2,6-bisphosphate 2-phosphatase Activity Protein Binding ATP Binding Protein Kinase Binding	Chromatin Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity AMP-activated Protein Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Histone Serine Kinase Activity Metal Ion Binding [hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity [acetyl-CoA Carboxylase] Kinase Activity
	Biological Process	Fructose Metabolic Process Fructose 2,6-bisphosphate Metabolic Process Glucose Catabolic Process Lactate Metabolic Process Glycolytic Process Response To Glucose Dephosphorylation Positive Regulation Of Insulin Secretion Positive Regulation Of Glucokinase Activity Positive Regulation Of Glycolytic Process Carbohydrate Phosphorylation	Protein Phosphorylation Fatty Acid Biosynthetic Process Cholesterol Biosynthetic Process Carnitine Shuttle Cell Cycle Arrest Signal Transduction Lipid Biosynthetic Process Positive Regulation Of Autophagy Negative Regulation Of Gene Expression Response To Muscle Activity Wnt Signaling Pathway Macroautophagy Positive Regulation Of Macroautophagy Regulation Of Macroautophagy Cellular Response To Nutrient Levels Negative Regulation Of TOR Signaling Cellular Response To Oxidative Stress Histone-serine Phosphorylation Intracellular Signal Transduction Cellular Response To Drug Cellular Response To Glucose Starvation Regulation Of Fatty Acid Biosynthetic Process Glucose Homeostasis Regulation Of Circadian Rhythm Negative Regulation Of Apoptotic Process Positive Regulation Of Glycolytic Process Rhythmic Process Fatty Acid Homeostasis Regulation Of Stress Granule Assembly Regulation Of Microtubule Cytoskeleton Organization Cellular Response To Calcium Ion Cellular Response To Glucose Stimulus Cellular Response To Prostaglandin E Stimulus Energy Homeostasis Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Cellular Protein Localization Negative Regulation Of Tubulin Deacetylation Positive Regulation Of Peptidyl-lysine Acetylation
Pathways		Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	Translocation of SLC2A4 (GLUT4) to the plasma membrane Macroautophagy AMPK inhibits chREBP transcriptional activation activity AMPK inhibits chREBP transcriptional activation activity Carnitine metabolism Activation of PPARGC1A (PGC-1alpha) by phosphorylation Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of TP53 Activity through Phosphorylation Lipophagy Activation of AMPK downstream of NMDARs
Drugs			Acetylsalicylic acid
Diseases
GWAS		Diastolic blood pressure ( 30224653) Estimated glomerular filtration rate ( 31152163)	Lymphocyte counts ( 22286170)
Interacting Genes		9 interacting genes: AKT1 GCK PRKAA1 PRKAA2 PRKACA PRKCA YWHAG YWHAQ YWHAZ	52 interacting genes: ABI2 ACACA ACACB AIMP2 APPBP2 C19orf47 CCNB1IP1 DNMT1 EEF2K EPM2A FOS GLI1 HAT1 HMBOX1 HNF4A HOMEZ KCTD1 KIF24 KIFC3 KRT31 KRTAP10-3 L3MBTL3 LEP MYOZ1 NECAB2 NONO NOTCH2NLA NRAP NUTM1 PBXIP1 PFKFB2 PRKAB1 PRKAG1 RBBP7 RBPMS RFX6 RPTOR SNW1 STK11 TCF4 TFAP2A TLE5 TMOD1 TRIP6 TSC22D4 UBE2I USHBP1 USP10 VPS52 WWP1 ZBTB8A ZNF397
Entrez ID		5208	5563
HPRD ID		01383	02735
Ensembl ID		ENSG00000123836	ENSG00000162409
Uniprot IDs		O60825	P54646
PDB IDs		5HTK	2H6D 2LTU 2YZA 3AQV 4CFE 4CFF 4ZHX 5EZV 5ISO 6B1U 6B2E 6BX6
Enriched GO Terms of Interacting Partners?
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