MAP3K20 and DDAH2

Number of citations of the paper that reports this interaction (PubMedID 21900206)
114

Data Source:
BioGRID (two hybrid)

		MAP3K20	DDAH2
Description		mitogen-activated protein kinase kinase kinase 20	dimethylarginine dimethylaminohydrolase 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Mitochondrion Cytosol Centriolar Satellite Extracellular Exosome
	Molecular Function	Magnesium Ion Binding RNA Binding Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding	Catalytic Activity Protein Binding Dimethylargininase Activity Amino Acid Binding Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amidines
	Biological Process	DNA Damage Checkpoint Activation Of MAPKK Activity Protein Phosphorylation Cytoskeleton Organization Cell Cycle Arrest Mitotic Cell Cycle Checkpoint Activation Of JUN Kinase Activity Cell Death Cell Differentiation Embryonic Digit Morphogenesis Positive Regulation Of Apoptotic Process Stress-activated MAPK Cascade Limb Development Cellular Response To Gamma Radiation	Citrulline Metabolic Process Arginine Metabolic Process Arginine Catabolic Process Nitric Oxide Biosynthetic Process Nitric Oxide Mediated Signal Transduction Negative Regulation Of Apoptotic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Nitric-oxide Synthase Activity
Pathways			eNOS activation
Drugs		Dasatinib	L-Citrulline
Diseases
GWAS			Asthma ( 31619474) Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Inflammatory bowel disease ( 28067908) Ulcerative colitis ( 28067908)
Interacting Genes		28 interacting genes: CCDC69 CRMP1 DDAH2 EZH2 IGHM ITSN1 MAP2K4 MAP2K6 MAP2K7 MIDN MPP1 NEDD4L RBX1 RNF19A RPS6KA5 SMARCB1 SRPK2 TGFBR1 UNC119 VPS33B YWHAG YWHAZ ZFP2 ZNF33A ZNF567 ZNF593 ZNF746 ZNF775	22 interacting genes: ANXA7 ATP1B1 CDC73 CDK4 CDKN1A DNAJB11 GADD45G MAP3K20 MKNK1 PIN1 RAP1B RCC1 RPS6KA1 RPS6KA5 SMN1 STK3 TAF1D TK1 TNFSF11 TRIP13 TSC22D1 VAC14
Entrez ID		51776	23564
HPRD ID		11791	09204
Ensembl ID		ENSG00000091436	ENSG00000213722
Uniprot IDs		D4Q8H0 Q9NYL2	O95865 V9HW53
PDB IDs		5HES 5X5O 6JUT
Enriched GO Terms of Interacting Partners?
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