ERAP1 and IL6R

Number of citations of the paper that reports this interaction (PubMedID 12748171)
25

Data Source:
HPRD (in vivo)

		ERAP1	IL6R
Description		endoplasmic reticulum aminopeptidase 1	interleukin 6 receptor
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Cytosol Membrane Integral Component Of Membrane Extracellular Exosome	Extracellular Region Plasma Membrane Interleukin-6 Receptor Complex External Side Of Plasma Membrane Basolateral Plasma Membrane Apical Plasma Membrane Receptor Complex Ciliary Neurotrophic Factor Receptor Complex
	Molecular Function	Aminopeptidase Activity Interleukin-6 Receptor Binding Interleukin-1, Type II Receptor Binding Protein Binding Metalloexopeptidase Activity Zinc Ion Binding Peptide Binding Metalloaminopeptidase Activity	Cytokine Receptor Activity Ciliary Neurotrophic Factor Receptor Activity Interleukin-6 Receptor Activity Interleukin-6 Receptor Binding Protein Binding Enzyme Binding Cytokine Binding Interleukin-6 Binding Protein Homodimerization Activity Ciliary Neurotrophic Factor Binding
	Biological Process	Angiogenesis Adaptive Immune Response Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Proteolysis Membrane Protein Ectodomain Proteolysis Regulation Of Blood Pressure Response To Bacterium Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Peptide Catabolic Process Regulation Of Innate Immune Response Fat Cell Differentiation Positive Regulation Of Angiogenesis	Hepatic Immune Response Monocyte Chemotaxis Positive Regulation Of Leukocyte Chemotaxis Acute-phase Response Positive Regulation Of Cell Proliferation Positive Regulation Of Activation Of Janus Kinase Activity Cytokine-mediated Signaling Pathway Endocrine Pancreas Development Positive Regulation Of Chemokine Production Positive Regulation Of Interleukin-6 Production Response To Cytokine Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Defense Response To Gram-negative Bacterium Interleukin-6-mediated Signaling Pathway Ciliary Neurotrophic Factor-mediated Signaling Pathway Positive Regulation Of Glomerular Mesangial Cell Proliferation Extrinsic Apoptotic Signaling Pathway
Pathways		Antigen Presentation: Folding, assembly and peptide loading of class I MHC	Interleukin-6 signaling MAPK3 (ERK1) activation MAPK1 (ERK2) activation Interleukin-4 and Interleukin-13 signaling Transcriptional regulation of granulopoiesis
Drugs			Tocilizumab Sarilumab
Diseases
GWAS		Acute anterior uveitis (with or without ankylosing spondylitis) ( 25200001) Acute anterior uveitis in ankylosing spondylitis ( 25200001) Alcohol dependence ( 19581569) Ankylosing spondylitis ( 23749187 21743469 20062062 30946743) Behcet's disease ( 23291587) Birdshot chorioretinopathy ( 24957906) Blood protein levels ( 30072576 29875488 28240269) Body mass index ( 26426971 29273807) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Colorectal cancer ( 25990418) Emotional lability in attention deficit hyperactivity disorder ( 31085060) Hodgkin's lymphoma ( 22286212) Inflammatory bowel disease ( 23128233) Inflammatory skin disease ( 25574825) Medication use (calcium channel blockers) ( 31015401) Psoriasis ( 25854761 20953190 25574825 23143594) Psoriasis vulgaris ( 26626624) Systolic blood pressure ( 30578418) Urate levels (BMI interaction) ( 25811787)	Abdominal aortic aneurysm ( 27899403) Acute anterior uveitis (with or without ankylosing spondylitis) ( 25200001) Albumin-globulin ratio ( 29403010) Allergic disease (asthma, hay fever or eczema) ( 29083406) Ankylosing spondylitis ( 23749187) Asthma ( 21907864) Atopic dermatitis ( 26482879) Atrial fibrillation ( 29892015) Blood protein levels ( 30072576 29875488 28240269 23696881) Blood protein levels in cardiovascular risk ( 28369058) C-reactive protein ( 19567438 18439548) C-reactive protein levels ( 29403010 30388399 21300955) Cerebrospinal fluid levels of Alzheimer's disease-related proteins ( 25340798) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Coronary artery disease ( 29212778 26343387) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Fibrinogen ( 20031577 23969696) Fibrinogen levels ( 28107422 26561523) Itch intensity from mosquito bite ( 28199695) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Monocyte percentage of white cells ( 27863252) Mosquito bite size ( 28199695) Myocardial infarction ( 26343387) Parental longevity (combined parental attained age, Martingale residuals) ( 29227965) Protein quantitative trait loci ( 18464913) Pulmonary function ( 17903307) Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy) ( 24554482) Rheumatoid arthritis ( 30423114 23143596 24390342) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Systemic lupus erythematosus ( 28714469)
Interacting Genes		3 interacting genes: H3-4 IL6R TNFRSF1A	10 interacting genes: ADRB2 CNTF ERAP1 IL6 IL6ST MAGI1 SRC STAT3 WWP1 WWP2
Entrez ID		51752	3570
HPRD ID		06015	01000
Ensembl ID		ENSG00000164307	ENSG00000160712
Uniprot IDs		Q9NZ08	A0A087WTB5 A0N0L5 P08887
PDB IDs		2YD0 3MDJ 3QNF 3RJO 5J5E 6Q4R	1N26 1N2Q 1P9M 2ARW 5FUC
Enriched GO Terms of Interacting Partners?
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