RAPGEF6 and NEDD4

Number of citations of the paper that reports this interaction (PubMedID 16055720)
81

Data Source:
BioGRID (pull down)

		RAPGEF6	NEDD4
Description		Rap guanine nucleotide exchange factor 6	NEDD4 E3 ubiquitin protein ligase
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GO Annotations	Cellular Component	Centrosome Cytosol Plasma Membrane Apical Plasma Membrane Endocytic Vesicle	Ubiquitin Ligase Complex Chromatin Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Cell Cortex Apicolateral Plasma Membrane Dendritic Spine Perinuclear Region Of Cytoplasm Extracellular Exosome Glutamatergic Synapse Postsynaptic Cytosol
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Ras GTPase Binding GTP-dependent Protein Binding Phosphatidic Acid Binding	Protein Binding Sodium Channel Inhibitor Activity Enzyme Binding Protein Domain Specific Binding Beta-2 Adrenergic Receptor Binding Ionotropic Glutamate Receptor Binding Ubiquitin Binding Phosphoserine Residue Binding Phosphothreonine Residue Binding Ubiquitin Protein Ligase Activity RNA Polymerase Binding Proline-rich Region Binding
	Biological Process	Ras Protein Signal Transduction Microvillus Assembly Regulation Of GTPase Activity Positive Regulation Of GTPase Activity Protein Localization To Plasma Membrane Establishment Of Endothelial Intestinal Barrier	Protein Polyubiquitination Adaptive Immune Response Outflow Tract Morphogenesis Endocardial Cushion Development Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Protein Targeting To Lysosome Lysosomal Transport Neuromuscular Junction Development Negative Regulation Of Sodium Ion Transport Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Regulation Of Macroautophagy Protein Ubiquitination Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Neuron Projection Development Receptor Internalization Receptor Catabolic Process Cellular Response To UV Regulation Of Ion Transmembrane Transport T Cell Activation Regulation Of Membrane Potential Glucocorticoid Receptor Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Development Involved In Symbiotic Interaction Positive Regulation Of Protein Catabolic Process Positive Regulation Of Nucleocytoplasmic Transport Blood Vessel Morphogenesis Regulation Of Dendrite Morphogenesis Regulation Of Synapse Organization Progesterone Receptor Signaling Pathway Response To Calcium Ion Protein K63-linked Ubiquitination Regulation Of Potassium Ion Transmembrane Transporter Activity Negative Regulation Of Sodium Ion Transmembrane Transporter Activity
Pathways			ISG15 antiviral mechanism Downregulation of ERBB4 signaling Regulation of PTEN localization Regulation of PTEN stability and activity Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Alzheimer's disease in APOE e4- carriers ( 25778476) Crohn's disease ( 28067908) Diisocyanate-induced asthma ( 25918132) Inflammatory bowel disease ( 28067908) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Mosquito bite size ( 28199695) Perceived unattractiveness to mosquitoes ( 28199695) Subjective well-being ( 27089181) Ulcerative colitis ( 28067908)	Brain connectivity ( 23471985) Chronic lymphocytic leukemia ( 28165464 24292274) Dupuytren's disease ( 28886342) Hip circumference adjusted for BMI ( 28552196) Intraocular pressure ( 29617998) Joint mobility (Beighton score) ( 27182965) Keloid ( 20711176) Stroke ( 29531354)
Interacting Genes		8 interacting genes: ABCA1 LINC00839 MRAS NEDD4 PTPN13 RAP1A RAP2A YWHAG	231 interacting genes: ABCB1 ABL1 ABL2 ADRB2 AKT3 AMOT AMOTL1 AMPD2 ANKRD13D ANXA13 AP1G2 ARID1A ASPSCR1 AURKC BAIAP2 BMPR1A BRCA2 CAD CALCOCO1 CAMK1D CAMK4 CAMKK2 CASP1 CASP3 CASP6 CASP7 CBLB CCNH CDC25C CDK5 CDK5R1 CLIC2 CLK3 CPSF1 CPSF6 CUEDC1 DAZAP2 DCUN1D1 DDX3X DDX54 DHX30 DIAPH1 DVL1 DYRK4 EBAG9 EGFR EPHA5 EPRS1 EPS15 ERBB3 ERBB4 ERMN ERRFI1 FES FGF12 FGF21 FGFR1 FGFR2 FKBP3 FLT1 FLT4 FYN GABARAP GABARAPL1 GABARAPL2 GBA GRB10 GRIN2A GRK4 GRK7 H3-3A HGS HMCES HNRNPK HNRNPL HNRNPU HNRNPUL1 IFITM3 IGF1R IRS1 IRS2 JHY JUN KCNAB1 KCNAB2 KCNJ16 KIFC3 LAPTM5 LATS1 LITAF LUC7L2 MAP1LC3A MAP1LC3B MAP1LC3C MAP3K2 MAP3K3 MAP3K5 MAP4K5 MAPKAPK3 MARK2 MARK4 MLANA MOB3A MRPL19 MTMR4 MYCN N4BP2 N4BP3 NDFIP1 NDFIP2 NFE2 NHP2 NSRP1 NUDT21 NUMB PARP16 PAX7 PDGFRB PIP5K1A PIP5K1C PKN2 PLK1 PLK2 PMEPA1 POLR2A POLR2B POLR2C POLR2E POLR2M POLR3A PRKG2 PRKX PRPF8 PRR16 PRRG1 PRRG2 PSMD4 PYM1 RAC1 RAD51AP1 RAF1 RANBP10 RAP2A RAPGEF2 RAPGEF6 RASGEF1A RASL11B RBCK1 RET RFT1 RNF11 RNF7 RPAP2 RPAP3 RPL18A RPS3A RPS6KA3 RPS6KA4 RPS6KB1 RUNX1 RUVBL1 SAAL1 SAMSN1 SAV1 SCAMP3 SCN5A SCNN1A SCNN1B SCNN1G SEPTIN9 SERTAD1 SFTPC SGK1 SGK2 SH3KBP1 SHTN1 SIVA1 SLC23A2 SLC6A3 SMAD1 SMAD3 SMAD5 SMARCC1 SMO SNCA SP140L SPANXN3 SPRY2 SRC SRMS SRSF7 STK24 STK25 STK26 STK31 STK4 SULF1 SYK SYT1 TAF1B TBC1D7 TBK1 TCEANC TCP11L1 TEAD2 THOC1 THRAP3 TNIK TOM1 TOM1L2 TP73 TRIM44 TRIM52 TRPV6 TSTA3 TTYH2 UBAP2L UBC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2L3 UBE2M UBOX5 URI1 WBP1 WBP2 WEE1 YES1 YOD1
Entrez ID		51735	4734
HPRD ID		11483	03786
Ensembl ID		ENSG00000158987	ENSG00000069869
Uniprot IDs		B2RTU6 Q8TEU7	P46934
PDB IDs		2D93 3LNY	2KPZ 2KQ0 2M3O 2XBB 2XBF 3B7Y 4BBN 4BE8 4N7F 4N7H 5AHT 5C7J 5C91
Enriched GO Terms of Interacting Partners?
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