RAB14 and ARHGEF17

		RAB14	ARHGEF17
Description		RAB14, member RAS oncogene family	Rho guanine nucleotide exchange factor 17
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Intracellular Lysosome Lysosomal Membrane Early Endosome Late Endosome Rough Endoplasmic Reticulum Golgi Stack Trans-Golgi Network Cytosol Plasma Membrane Cilium Endomembrane System Trans-Golgi Network Transport Vesicle Early Endosome Membrane Nuclear Outer Membrane-endoplasmic Reticulum Membrane Network Intracellular Membrane-bounded Organelle Phagocytic Vesicle Perinuclear Region Of Cytoplasm Recycling Endosome Recycling Endosome Membrane Extracellular Exosome Tertiary Granule Membrane	Cytosol
	Molecular Function	GTPase Activity Protein Binding GTP Binding GDP Binding Myosin V Binding	Guanyl-nucleotide Exchange Factor Activity Rho Guanyl-nucleotide Exchange Factor Activity
	Biological Process	Phosphatidylinositol Biosynthetic Process Intracellular Protein Transport Golgi To Endosome Transport Fibroblast Growth Factor Receptor Signaling Pathway Vesicle-mediated Transport Endocytic Recycling Rab Protein Signal Transduction Regulation Of Protein Localization Defense Response To Bacterium Neutrophil Degranulation Regulation Of Embryonic Development Intracellular Transport Phagolysosome Assembly Involved In Apoptotic Cell Clearance	G Protein-coupled Receptor Signaling Pathway Actin Cytoskeleton Organization Positive Regulation Of Apoptotic Process Regulation Of Small GTPase Mediated Signal Transduction
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane Synthesis of PIPs at the plasma membrane Neutrophil degranulation RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs	NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events
Drugs
Diseases
GWAS		Immune reponse to smallpox (secreted IFN-alpha) ( 22610502)	FEV1 ( 30804560) GIP levels in response to oral glucose tolerance test (120 minutes) ( 29093273) Lung function (FEV1/FVC) ( 30804560) Peak expiratory flow ( 30804560)
Interacting Genes		16 interacting genes: APP ARHGEF17 CHM EXOC5 FGA GSN NR5A1 OCRL OPTN RAB11FIP5 RBSN RUFY1 SMURF2 TLR4 TNC XRN2	1 interacting genes: RAB14
Entrez ID		51552	9828
HPRD ID		06693	10658
Ensembl ID		ENSG00000119396	ENSG00000110237
Uniprot IDs		A0A024R845 P61106	Q96PE2
PDB IDs		1Z0F 4D0G 4DRZ
Enriched GO Terms of Interacting Partners?
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