HACD3 and HMGB2

Number of citations of the paper that reports this interaction (PubMedID 29721183)
2

Data Source:
BioGRID (two hybrid)

		HACD3	HMGB2
Description		3-hydroxyacyl-CoA dehydratase 3	high mobility group box 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Focal Adhesion Integral Component Of Endoplasmic Reticulum Membrane Nuclear Membrane	Nuclear Chromatin Condensed Chromosome Extracellular Space Cell Nucleus Nucleoplasm Nucleolus Cytoplasm Protein-containing Complex Perinuclear Region Of Cytoplasm
	Molecular Function	GTPase Activator Activity Protein Binding 3-hydroxyacyl-CoA Dehydratase Activity Enzyme Binding Very-long-chain 3-hydroxyacyl-CoA Dehydratase Activity 3-hydroxy-arachidoyl-CoA Dehydratase Activity 3-hydroxy-behenoyl-CoA Dehydratase Activity 3-hydroxy-lignoceroyl-CoA Dehydratase Activity	Four-way Junction DNA Binding Proximal Promoter Sequence-specific DNA Binding DNA Binding Damaged DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Transcription Coactivator Activity RNA Binding Protein Binding Transcription Factor Binding Drug Binding DNA Binding, Bending Protein Domain Specific Binding Chemoattractant Activity Transcription Regulatory Region DNA Binding Non-sequence-specific DNA Binding, Bending RAGE Receptor Binding Supercoiled DNA Binding
	Biological Process	I-kappaB Kinase/NF-kappaB Signaling Activation Of JUN Kinase Activity Small GTPase Mediated Signal Transduction Rho Protein Signal Transduction Rac Protein Signal Transduction Sphingolipid Biosynthetic Process Fatty Acid Elongation Very Long-chain Fatty Acid Biosynthetic Process Positive Regulation Of GTPase Activity Positive Regulation Of Viral Genome Replication Positive Regulation By Virus Of Viral Protein Levels In Host Cell	Positive Regulation Of Endothelial Cell Proliferation Inflammatory Response To Antigenic Stimulus DNA Topological Change Apoptotic DNA Fragmentation DNA Recombination Chromatin Organization Nucleosome Assembly Chromatin Remodeling Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Spermatid Nucleus Differentiation Male Gonad Development Positive Regulation Of Nuclease Activity DNA Geometric Change Response To Lipopolysaccharide Positive Regulation Of Interferon-beta Production V(D)J Recombination Response To Drug Positive Regulation Of DNA Binding Innate Immune Response Positive Regulation Of Innate Immune Response Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Megakaryocyte Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Response To Steroid Hormone Regulation Of Neurogenesis Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Positive Chemotaxis DNA Ligation Involved In DNA Repair Cell Chemotaxis Cellular Response To Lipopolysaccharide Regulation Of Stem Cell Proliferation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Pathways		Synthesis of very long-chain fatty acyl-CoAs	Apoptosis induced DNA fragmentation
Drugs
Diseases
GWAS
Interacting Genes		2 interacting genes: HMGB2 RAC1	37 interacting genes: APEX1 APP AR ARCN1 C1QBP CACTIN CHAF1A CREBBP CSNK1A1 EIF1 FBXO7 GZMA GZMK H3-3A HACD3 HDLBP HMGA1 LZTS1 MIEN1 NAP1L1 NCBP3 NEXN NR3C1 PGR PKNOX1 POU2F1 POU2F2 POU3F1 POU5F1 PRKDC RAG1 SAMM50 SET TP53 ZNF428 ZNF622 ZNF668
Entrez ID		51495	3148
HPRD ID		11037	01229
Ensembl ID		ENSG00000074696	ENSG00000164104
Uniprot IDs		H3BRL8 Q9P035	P26583
PDB IDs
Enriched GO Terms of Interacting Partners?
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