SNX9 and PIK3R5

Number of citations of the paper that reports this interaction (PubMedID 17242350)
34

Data Source:
BioGRID (pull down)

		SNX9	PIK3R5
Description		sorting nexin 9	phosphoinositide-3-kinase regulatory subunit 5
Image			No pdb structure
GO Annotations	Cellular Component	Ruffle Cytoplasm Trans-Golgi Network Cytosol Plasma Membrane Clathrin-coated Vesicle Cytoplasmic Vesicle Membrane Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Cytoplasmic Vesicle Cuticular Plate Extracellular Exosome	Nucleus Cytoplasm Cytosol Plasma Membrane Phosphatidylinositol 3-kinase Complex Phosphatidylinositol 3-kinase Complex, Class IB Membrane Centriolar Satellite
	Molecular Function	Protein Binding 1-phosphatidylinositol Binding Ubiquitin Protein Ligase Binding Phosphatidylinositol Binding Identical Protein Binding Protein Homodimerization Activity Cadherin Binding Arp2/3 Complex Binding	G-protein Beta/gamma-subunit Complex Binding 1-phosphatidylinositol-3-kinase Regulator Activity
	Biological Process	Mitotic Cytokinesis Intracellular Protein Transport Endocytosis Receptor-mediated Endocytosis Endosomal Transport Positive Regulation Of Actin Filament Polymerization Cleavage Furrow Formation Positive Regulation Of GTPase Activity Positive Regulation Of Protein Kinase Activity Positive Regulation Of Membrane Protein Ectodomain Proteolysis Lipid Tube Assembly Membrane Organization Protein-containing Complex Assembly Plasma Membrane Tubulation	Phosphatidylinositol Biosynthetic Process G Protein-coupled Receptor Signaling Pathway Phosphatidylinositol 3-kinase Signaling Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Platelet Activation Positive Regulation Of MAP Kinase Activity Regulation Of Phosphatidylinositol 3-kinase Activity Positive Regulation Of Protein Kinase B Signaling
Pathways		Golgi Associated Vesicle Biogenesis Clathrin-mediated endocytosis	GPVI-mediated activation cascade Synthesis of PIPs at the plasma membrane G beta:gamma signalling through PI3Kgamma Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
Drugs
Diseases
GWAS		Borderline personality disorder ( 28632202) Heart rate response to beta blockers ( 29478026) Lipoprotein (a) - cholesterol levels ( 25575512) Metabolite levels ( 23823483) Platelet distribution width ( 27863252)	Atypical femoral fracture in phosphonate treatment ( 31006051)
Interacting Genes		22 interacting genes: ADAM15 ADAM9 CLTC DAPK1 DNM1 DNM2 EGFR FASLG ITCH KHDRBS1 LRRK1 MPHOSPH6 MPP6 PAK2 PI4KA PIK3CA PIK3R5 SOS1 SOS2 TNK2 WAS WASL	4 interacting genes: APP PIK3CG SDHB SNX9
Entrez ID		51429	23533
HPRD ID		12072	11433
Ensembl ID		ENSG00000130340	ENSG00000141506
Uniprot IDs		Q9Y5X1	J3KSW1 L7RT34 Q8WYR1
PDB IDs		2RAI 2RAJ 2RAK 3DYT 3DYU 3LGE
Enriched GO Terms of Interacting Partners?
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