CSAD and RAP1B

Number of citations of the paper that reports this interaction (PubMedID 21900206)
114

Data Source:
BioGRID (two hybrid)

		CSAD	RAP1B
Description		cysteine sulfinic acid decarboxylase	RAP1B, member of RAS oncogene family
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GO Annotations	Cellular Component	Cytoplasm	Intracellular Lipid Droplet Cytosol Plasma Membrane Cell-cell Junction Membrane Azurophil Granule Membrane Membrane Raft Extracellular Exosome
	Molecular Function	Aspartate 1-decarboxylase Activity Sulfinoalanine Decarboxylase Activity Pyridoxal Phosphate Binding	GTPase Activity Protein Binding GTP Binding GDP Binding Protein-containing Complex Binding
	Biological Process	L-cysteine Catabolic Process To Hypotaurine L-cysteine Catabolic Process To Taurine Taurine Biosynthetic Process	Cell Proliferation Response To Carbohydrate Microvillus Assembly Rap Protein Signal Transduction Positive Regulation Of Integrin Activation Cellular Response To Drug Interleukin-12-mediated Signaling Pathway Neutrophil Degranulation Negative Regulation Of Calcium Ion-dependent Exocytosis Establishment Of Endothelial Barrier Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To CAMP Cellular Response To Gonadotropin-releasing Hormone Regulation Of Cell Junction Assembly Regulation Of Establishment Of Cell Polarity Negative Regulation Of Synaptic Vesicle Exocytosis
Pathways		Degradation of cysteine and homocysteine	Integrin signaling GRB2:SOS provides linkage to MAPK signaling for Integrins p130Cas linkage to MAPK signaling for integrins Rap1 signalling MAP2K and MAPK activation Neutrophil degranulation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF MET activates RAP1 and RAC1 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation Signaling downstream of RAS mutants
Drugs		Pyridoxal Phosphate Pyridoxal Phosphate L-Cysteine
Diseases
GWAS		Fulminant type 1 diabetes ( 30552108) Obesity-related traits ( 23251661)	White blood cell count ( 20139978)
Interacting Genes		11 interacting genes: ANXA1 ANXA7 CDKN1A GSK3B NR1H2 PIN1 RAP1B RCC1 SH2B1 SMN1 TK1	29 interacting genes: A2M ALAS1 APLP1 APP CCT7 CHGB CSAD DDAH2 FAF1 HRAS KMT2B LRIF1 PDHB PKM PRKACA RAB7B RALGDS RAPGEF1 RASSF5 RGL2 RGS2 RPTOR SDF4 SMURF2 TLE1 TP53 UNC119 ZDHHC17 ZNF135
Entrez ID		51380	5908
HPRD ID		16763	01546
Ensembl ID		ENSG00000139631	ENSG00000127314
Uniprot IDs		A0A024RAX7 Q86V02 Q96JQ3 Q9Y600	A0A024RB87 B7ZAY2 P61224
PDB IDs		2JIS	3BRW 3CF6 4DXA 4HDO 4HDQ 4M8N 4MGI 4MGK 4MGY 4MGZ 4MH0 5KHO 6AXF 6BA6
Enriched GO Terms of Interacting Partners?
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