DACT1 and C7orf25

Number of citations of the paper that reports this interaction (PubMedID 21900206)
114

Data Source:
BioGRID (two hybrid)

		DACT1	C7orf25
Description		dishevelled binding antagonist of beta catenin 1	chromosome 7 open reading frame 25
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cell Junction Beta-catenin Destruction Complex Synapse
	Molecular Function	RNA Polymerase II Transcription Factor Binding Protein Kinase C Binding Protein Binding Beta-catenin Binding Histone Deacetylase Binding Protein Kinase A Binding Delta-catenin Binding	Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Wnt Signaling Pathway Neural Tube Development Regulation Of Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Regulation Of Protein Stability Negative Regulation Of Protein Binding Positive Regulation Of Protein Binding Positive Regulation Of Protein Catabolic Process Negative Regulation Of JNK Cascade Embryonic Hindgut Morphogenesis Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of Nodal Signaling Pathway Positive Regulation Of Cellular Protein Catabolic Process Negative Regulation Of Beta-catenin-TCF Complex Assembly Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		Degradation of DVL
Drugs
Diseases
GWAS		Colorectal cancer or advanced adenoma ( 30510241) Dentate gyrus granule cell layer volume (corrected for total hippocampal volume) ( 30279459) Hippocampal subfield CA1 volume (corrected for total hippocampal volume) ( 30279459) Hippocampal tail volume (corrected for total hippocampal volume) ( 30279459) Metabolite levels ( 23823483) Occipital lobe volume ( 31396565) Parietal lobe volume ( 31396565)	Asthma ( 29273806)
Interacting Genes		5 interacting genes: C7orf25 CSNK2B PPP1CC SH3GL2 TK1	19 interacting genes: BRD4 CEP70 CRYM DACT1 EZH2 FRA10AC1 FYN FZR1 HAP1 HEXD MTOR MX1 NGEF PTN RASSF1 RPL36AL SF3B2 TARS1 UBE2D1
Entrez ID		51339	79020
HPRD ID		09709	09861
Ensembl ID		ENSG00000165617	ENSG00000136197
Uniprot IDs		B7Z673 Q9NYF0	Q9BPX7
PDB IDs
Enriched GO Terms of Interacting Partners?
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