PCSK2 and IAPP

Number of citations of the paper that reports this interaction (PubMedID 3053705)
41

Data Source:
HPRD (in vitro, in vivo)

		PCSK2	IAPP
Description		proprotein convertase subtilisin/kexin type 2	islet amyloid polypeptide
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Nucleoplasm Trans-Golgi Network Membrane Transport Vesicle Secretory Granule Integral Component Of Golgi Membrane Dendrite Perikaryon Intracellular Membrane-bounded Organelle	Extracellular Region Extracellular Space Cell Neuronal Cell Body
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Protein-containing Complex Binding	Amyloid-beta Binding Signaling Receptor Binding Hormone Activity Protein Binding Identical Protein Binding
	Biological Process	Proteolysis Nervous System Development Protein Processing Peptide Hormone Processing Protein Autoprocessing Insulin Processing Enkephalin Processing Islet Amyloid Polypeptide Processing	Apoptotic Process Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Positive Regulation Of Protein Kinase A Signaling Negative Regulation Of Mitochondrion Organization Sensory Perception Of Pain Negative Regulation Of Protein Complex Assembly Eating Behavior Positive Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Cellular Protein Metabolic Process Negative Regulation Of Cell Differentiation Negative Regulation Of Bone Resorption Positive Regulation Of Protein Kinase B Signaling Amylin Receptor Signaling Pathway Negative Regulation Of Amyloid Fibril Formation
Pathways		Insulin processing	Regulation of gene expression in beta cells G alpha (s) signalling events Calcitonin-like ligand receptors ADORA2B mediated anti-inflammatory cytokines production Amyloid fiber formation
Drugs		Insulin Human Insulin Pork	Copper
Diseases
GWAS		Biochemical measures ( 19260141) Chronotype ( 30696823) Dialysis-related mortality ( 21546767) Familial lung cancer ( 29924316) Loneliness ( 27629369) Menarche (age at onset) ( 21102462 25231870) Morning person ( 30696823) Obesity-related traits ( 23251661) Preschool internalizing problems ( 24839885) Response to fenofibrate (triglyceride levels) ( 27002377)	Diisocyanate-induced asthma ( 25918132)
Interacting Genes		3 interacting genes: IAPP PMCH SCG5	6 interacting genes: COL25A1 PCSK1 PCSK2 PDX1 RAMP1 RAMP2
Entrez ID		5126	3375
HPRD ID		01202	01005
Ensembl ID		ENSG00000125851	ENSG00000121351
Uniprot IDs		P16519	A0A024RAU1 P10997
PDB IDs			1KUW 2G48 2KB8 2L86 3DG1 3FPO 3FR1 3FTH 3FTK 3FTL 3FTR 3G7V 3G7W 3HGZ 5K5G 5KNZ 5KO0 5MGQ
Enriched GO Terms of Interacting Partners?
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