PLCE1 and GHITM

		PLCE1	GHITM
Description		phospholipase C epsilon 1	growth hormone inducible transmembrane protein
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cell Cytosol Plasma Membrane	Mitochondrion Mitochondrial Inner Membrane Integral Component Of Membrane Extracellular Exosome
	Molecular Function	Phosphatidylinositol Phospholipase C Activity Phospholipase C Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding Ras GTPase Binding Enzyme Binding Metal Ion Binding	Molecular_function Protein Binding
	Biological Process	Activation Of MAPK Activity Regulation Of Cell Growth Diacylglycerol Biosynthetic Process Regulation Of Smooth Muscle Contraction Cytoskeleton Organization Epidermal Growth Factor Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Ras Protein Signal Transduction Heart Development Regulation Of G Protein-coupled Receptor Signaling Pathway Lipid Catabolic Process Calcium-mediated Signaling Glomerulus Development Inositol Trisphosphate Biosynthetic Process Inositol Phosphate Metabolic Process Regulation Of Protein Kinase Activity Regulation Of Ras Protein Signal Transduction Phosphatidylinositol-mediated Signaling Inositol Phosphate-mediated Signaling Release Of Sequestered Calcium Ion Into Cytosol	Apoptotic Process Biological_process
Pathways		Synthesis of IP3 and IP4 in the cytosol
Drugs
Diseases		Nephrotic syndrome and focal segmental glomerulosclerosis
GWAS		Birth weight ( 31043758) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Coronary artery disease ( 29212778) Dengue shock syndrome ( 22001756) Diastolic blood pressure ( 27841878 21909115 27618452) Esophageal cancer ( 21642993) Esophageal cancer and gastric cancer ( 20729852) Esophageal squamous cell carcinoma ( 25129146) Glaucoma ( 31959993) Glaucoma (primary open-angle) ( 29891935) Glucose homeostasis traits ( 25524916) Hypertension ( 31879980 21909115) Lifetime average cigarettes per day in chronic obstructive pulmonary disease ( 21685187) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Migraine ( 27182965 27322543) Offspring birth weight ( 31043758) Optic cup area ( 31798171) Personality traits in bipolar disorder ( 21368711) Plasma clozapine-norclozapine ratio in treatment-resistant schizophrenia ( 30922102) Plateletcrit ( 27863252) Pulse pressure ( 27841878 28739976 30578418) Response to (pegylated) interferon in chronic hepatitis B ( 30715261) Sudden cardiac arrest ( 21658281) Systolic blood pressure ( 27841878 21909115 28739976 27618452 30578418) Vertical cup-disc ratio ( 31798171 25241763) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for body mass index ( 28448500)	Abstraction and mental flexibility ( 31596458) Influenza A (H1N1) infection ( 26379185) Metabolite levels ( 23823483) Mild influenza (H1N1) infection ( 26379185)
Interacting Genes		4 interacting genes: GHITM HRAS KIT NRAS	5 interacting genes: CCSER2 DYDC1 DYDC2 KLLN PLCE1
Entrez ID		51196	27069
HPRD ID		07087	17038
Ensembl ID		ENSG00000138193	ENSG00000165678
Uniprot IDs		B7ZM61 Q9P212	Q9H3K2
PDB IDs		2BYE 2BYF 2C5L
Enriched GO Terms of Interacting Partners?
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