INSIG2 and LMNA

Number of citations of the paper that reports this interaction (PubMedID 24623722)
26

Data Source:
BioGRID (two hybrid)

		INSIG2	LMNA
Description		insulin induced gene 2	lamin A/C
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GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane SREBP-SCAP-Insig Complex	Nucleus Nuclear Envelope Lamin Filament Nucleoplasm Cytosol Nuclear Body Nuclear Speck Nuclear Membrane
	Molecular Function	Protein Binding Transcription Factor Binding	Protein Binding
	Biological Process	Triglyceride Metabolic Process Cholesterol Biosynthetic Process Negative Regulation Of Steroid Biosynthetic Process Response To Insulin SREBP Signaling Pathway Inner Ear Morphogenesis Middle Ear Morphogenesis Negative Regulation Of Fatty Acid Biosynthetic Process Roof Of Mouth Development Cranial Suture Morphogenesis Response To Fatty Acid	Protein Import Into Nucleus Mitotic Nuclear Envelope Reassembly Negative Regulation Of Cell Proliferation Positive Regulation Of Gene Expression Regulation Of Cell Migration Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity Regulation Of Protein Stability Protein Localization To Nucleus IRE1-mediated Unfolded Protein Response Ventricular Cardiac Muscle Cell Development Cellular Response To Hypoxia Negative Regulation Of Mesenchymal Cell Proliferation Negative Regulation Of Release Of Cytochrome C From Mitochondria Positive Regulation Of Cell Aging Positive Regulation Of Histone H3-K9 Trimethylation Regulation Of Protein Localization To Nucleus Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Regulation of cholesterol biosynthesis by SREBP (SREBF)	XBP1(S) activates chaperone genes Signaling by BRAF and RAF fusions
Drugs
Diseases			Restrictive dermopathy Emery-Dreifuss muscular dystrophy Dilated cardiomyopathy (DCM) Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy Mandibuloacral dysplasia Congenital muscular dystrophies (CMD/MDC), including: Merosin-deficient CMD (MDC1A); Ullrich CMD (UCMD); Integrin alpha7-deficient CMD; CMD with joint hyperlaxity (CMDH); CMD with epidermolysis bullosa; Walker-Warburg syndrome (WWS); Muscle-eye-brain disease (MEB); Fukuyama CMD (FCMD); CMD with muscle hypertrophy (MDC1C); CMD with severe intellectual impairment and abnormal glycosylation (MDC1D); Rigid spine syndrome (RSS); LMNA-deficient CMD; CMD with respiratory failure and muscle hypertrophy (MDC1B); Bethlem myopathy Limb-girdle muscular dystrophy (LGMD) Familial partial lipodystrophy (FPL), including the following four diseases: Kobberling-type lipodystrophy (FPLD1); Dunnigan-type lipodystrophy (FPLD2); Dunnigan-like lipodystrophy (FPLD3); AKT2 associated lipodystrophy Hutchinson-Gilford progeria syndrome
GWAS		Cholesterol, total ( 24097068) Depression in response to interferon-based therapy in chronic hepatitis C ( 27723809) Heel bone mineral density ( 30598549 28869591) LDL cholesterol ( 24097068 30275531) LDL cholesterol levels ( 30698716) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Lumbar spine bone mineral density ( 22504420) Monobrow ( 27182965) Mosquito bite size ( 28199695) Total cholesterol levels ( 30275531)	Birth weight ( 31043758) Ischemic heart disease in rheumatoid arthritis ( 30251476) Lung cancer in ever smokers ( 28604730) Ovarian cancer ( 30557369) Urate levels ( 31578528)
Interacting Genes		9 interacting genes: LMNA PSMA7 PSMB1 PSMC3 PSMC5 RNF5 SCAP SREBF2 VCP	378 interacting genes: ABCA9 ACOT7 ACTB ADAM33 ADGRE2 ADGRG7 AGTRAP AIG1 AKTIP ALG3 ALG8 ALOX12 ALOX12B ANKRD20A5P ANXA6 AOC3 APOA2 APOD APOL2 AQP1 AQP10 AQP3 ARHGEF16 ARL6IP1 ASGR1 ATP6V0C BCL2L2 BNIP2 BNIP3 BNIP3L BRICD5 BTN2A2 BYSL C11orf24 C1QTNF1 C20orf141 C3orf52 C4orf3 C5 CACNG1 CASP1 CASP6 CCDC120 CCNG1 CD52 CD72 CD81 CDK1 CDS2 CENPP CETN3 CFHR5 CHST1 CLCA4 CLCN7 CLDN10 CLDND2 CLEC1A CLEC4A CLK1 CLN6 CMTM3 CMTM5 CMTM7 CNIH3 COL8A2 COX14 CREB3 CRY2 CSGALNACT2 CTSA CWF19L2 CXCL14 CXCL16 CYB561 CYB561D2 CYB5B CYBC1 CYBRD1 DBNDD2 DDX24 DDX43 DEFB127 DERL1 DERL2 DNAJC30 DUS3L DUSP13 EDDM3B EGF EIF3G ELOA EMD ENTPD3 ERG28 F2RL1 FA2H FAIM FAM161A FAM3C FAM9B FATE1 FAXDC2 FBXO7 FCER1A FCER1G FDFT1 FETUB FLNA FOS FXYD3 FXYD6 GALNT2 GIN1 GJB2 GJB5 GOLGA2P10 GOLT1B GOSR2 GPR108 GPR25 GRM2 GZMA GZMB HACD1 HCK HMOX1 HMOX2 IFFO1 IFIT2 IGFBP5 INSIG2 ITGAM ITM2B IZUMO2 JAGN1 KASH5 KAT5 KCNK1 KCNK13 KIF12 KPNA6 KRT6A KRTAP10-3 KRTAP10-7 LAMB1 LAT LCP2 LEPROTL1 LHFPL5 LIMS2 LINC01587 LMBR1 LMNB1 LMNB2 LPAR3 LRP10 LVRN MAL MALL MAPRE2 MARVELD1 MATR3 MCM5 MEOX1 MFAP1 MFSD5 MGLL MGST3 MIP MLIP MMD2 MORF4L1 MRPS26 MS4A1 MTHFD2 MUTYH MYADM NAB2 NALCN NARF NAT8 NEU1 NINJ2 NIPAL3 NKG7 NOD2 NTAQ1 ORMDL1 ORMDL3 OSBPL8 OSTCP1 OSTF1 PAQR5 PARPBP PCBP1 PCGF2 PCNA PERM1 PIAS2 PIK3R2 PKD2 PLLP PLP1 PLP2 PLPP4 PMP22 PNKP PNLIPRP1 PRELID3A PRKCA PRNP PTPN9 RABAC1 RANBP9 RB1 RBBP4 REEP6 RGS18 RHAG RMDN2 RNF123 RPRM RTN1 RTN3 RTN4 RUSF1 SACM1L SBDS SCARA3 SCARB2 SEC22A SEC22B SELENOK SENP2 SERP1 SERP2 SERPINE1 SFT2D2 SFTPC SGMS2 SH3RF2 SIAH1 SLC13A3 SLC1A1 SLC2A5 SLC30A2 SLC30A3 SLC30A8 SLC35A1 SLC35A4 SLC35B2 SLC35B4 SLC38A7 SLC41A2 SLC7A1 SLN SLU7 SMAD1 SMAD3 SMCO4 SMIM11A SMURF1 SMURF2 SNORC SPANXC SPANXD SPG21 SPN SREBF1 SRPK2 STAC STAC2 STARD3 STX12 STX3 STX4 STX5 STX6 STX7 STX8 SUMO4 SVIL SYCE1 SYNE1 SYNGR1 SYPL1 SYT6 TAP1 TCEA2 TCEANC TDO2 TFRC THBD TM4SF20 TMEM107 TMEM109 TMEM11 TMEM120B TMEM128 TMEM140 TMEM14A TMEM14B TMEM14C TMEM199 TMEM201 TMEM203 TMEM208 TMEM218 TMEM222 TMEM230 TMEM234 TMEM243 TMEM267 TMEM41A TMEM42 TMEM43 TMEM51 TMEM54 TMEM60 TMEM65 TMEM74 TMEM86A TMPO TMPRSS4 TNF TNFRSF10C TNFSF12 TNMD TOR1A TOR1AIP1 TRAM1L1 TRIM26 TRIM39 TSGA10 TSNARE1 TSPAN2 TSPAN33 TSPAN7 UBE2I UBE2Q1 UBQLNL UCHL5 UNC13D UNC45A UNC50 UPK1B URB2 USE1 USP2 USP20 VAMP1 VAMP2 VAMP3 VAMP4 VAMP5 VKORC1 VMP1 VSTM1 VTI1B WFDC2 YIPF1 YIPF6 YWHAQ ZC2HC1C ZDHHC15 ZDHHC24 ZMYM6 ZNF138 ZNF239 ZNF25 ZNF3 ZNF439 ZNF440 ZNF490 ZNF569 ZNF69 ZSCAN12
Entrez ID		51141	4000
HPRD ID		16361	01035
Ensembl ID		ENSG00000125629	ENSG00000160789
Uniprot IDs		A0A024RAI2 B4DQ23 Q9Y5U4	A0A384MQX1 P02545 Q5TCI8
PDB IDs		4J82	1IFR 1IVT 1X8Y 2XV5 2YPT 3GEF 3V4Q 3V4W 3V5B 6GHD 6JLB 6SNZ
Enriched GO Terms of Interacting Partners?
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