COPS7A and EIF3E

Number of citations of the paper that reports this interaction (PubMedID 12220626)
26

Data Source:
HPRD (in vivo)

		COPS7A	EIF3E
Description		COP9 signalosome subunit 7A	eukaryotic translation initiation factor 3 subunit E
Image
GO Annotations	Cellular Component	Nucleoplasm Cytosol COP9 Signalosome	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 3 Complex Membrane Eukaryotic 43S Preinitiation Complex PML Body Eukaryotic 48S Preinitiation Complex Extracellular Exosome Eukaryotic Translation Initiation Factor 3 Complex, EIF3e
	Molecular Function	Protein Binding	RNA Binding Translation Initiation Factor Activity Protein Binding Cadherin Binding Protein N-terminus Binding
	Biological Process	Protein Deneddylation Nucleotide-excision Repair, DNA Damage Recognition Transcription-coupled Nucleotide-excision Repair COP9 Signalosome Assembly Viral Process Post-translational Protein Modification	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Formation Of Cytoplasmic Translation Initiation Complex Translational Initiation Regulation Of Translational Initiation Positive Regulation Of Translation Negative Regulation Of Translational Initiation Positive Regulation Of MRNA Binding
Pathways		DNA Damage Recognition in GG-NER Formation of TC-NER Pre-Incision Complex Cargo recognition for clathrin-mediated endocytosis Neddylation	L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit
Drugs
Diseases
GWAS			Coffee consumption ( 31046077) Dupuytren's disease ( 28886342 21732829) Heel bone mineral density ( 30598549) Macular thickness ( 30535121) Male-pattern baldness ( 28196072) Ossification of the posterior longitudinal ligament of the spine ( 25064007)
Interacting Genes		19 interacting genes: COPS2 COPS3 COPS4 COPS5 COPS8 CPEB2 CSNK2A1 CSNK2B CUL5 EIF3E GPS1 NFE2L2 PMF1 PPBP PRKD1 PTGS2 RAF1 TOM1L1 TP53	25 interacting genes: ATM C4orf19 COPS6 COPS7A COPS7B COPS8 DDX24 EIF3C EIF3L EIF4ENIF1 EPAS1 GPAA1 GPBP1L1 HAP1 IFIT1 MAPK1IP1L NDRG1 NSF PRRC2A RUNDC3A SHBG SMAD9 TRIM27 TRIM55 TRIM63
Entrez ID		50813	3646
HPRD ID		16736	03734
Ensembl ID		ENSG00000111652	ENSG00000104408
Uniprot IDs		Q9UBW8	P60228
PDB IDs		4D10 4D18 4WSN	3J8B 3J8C 6FEC
Enriched GO Terms of Interacting Partners?
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