ARHGEF4 and APC

  • Number of citations of the paper that reports this interaction (PubMedID 10947987)
  • 97
  • Data Source:
  • HPRD (two hybrid, in vivo, in vitro)

ARHGEF4

APC

Description Rho guanine nucleotide exchange factor 4 APC regulator of WNT signaling pathway
Image
GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Degraded stimulus continuous performance test score ( 31596458)
  • Progression free survival in metastatic colorectal cancer (CAPOX-B vs CAPOX-B plus cetuximab) ( 26222057)
  • Angiotensin-converting enzyme inhibitor intolerance ( 28030426)
  • Body mass index ( 29273807)
  • Colorectal cancer or advanced adenoma ( 30510241)
  • Heel bone mineral density ( 30598549)
  • Reaction time ( 29844566)
  • Total body bone mineral density ( 29304378)
Interacting Genes 5 interacting genes: APC HLA-B KHDRBS1 RAC1 RHOA 123 interacting genes: ACTN1 ADGRL1 AGFG1 AGR3 ANKRD17 ANXA7 AP2B1 ARHGEF4 ASAP2 AXIN1 AXIN2 BUB1 BUB1B C4A CASC3 CCL5 CGNL1 COG4 COG5 CREBBP CSNK1A1 CSNK1E CTBP1 CTNNA1 CTNNB1 CYP17A1 CYTH2 DIRAS3 DKK3 DLG3 DLGAP1 DST EPAS1 ERBIN EXPH5 FAM214A FBXO30 FHOD1 FLNA GIGYF2 GOLGA2 GSK3B HGS HNRNPM HOXC6 HSPA5 HTRA2 IL24 ING5 IQGAP1 JUP KIAA1328 KIF5B KIFAP3 KRT13 KRT14 KRT15 KRT17 KRT19 KRT23 KRT5 LAMA3 LAMA4 MACF1 MAPRE1 MAPRE2 MBD5 MCM3AP MKRN1 MT-ND4 MUC1 MYH10 MYH11 MYO6 NAT2 NAV1 NAV2 NAV3 NCKAP5 NCKAP5L NEB NOSTRIN NUP153 NUP214 NUP42 NUP54 NUP58 NUP98 PDLIM2 PNISR POM121 POM121C PPP1R13B PPP2CA PPP2R5A PRKACA PSMD1 PTPN13 RANBP9 RBM4B RP1 RPS27 SCRIB SEC31A SETDB1 SIAH1 SMC3 SNRNP200 SPECC1L SPTBN1 SPTBN2 ST14 SYNE1 TAF1 TFAP2A TFF1 TPR TRIM21 TRIM25 TUBA4A XPO1 YWHAQ ZNF106
Entrez ID 50649 324
HPRD ID 05559 01439
Ensembl ID ENSG00000136002 ENSG00000134982
Uniprot IDs Q9NR80 Q9NTG0 P25054 Q4LE70
PDB IDs 2DX1 2PZ1 3NMX 3NMZ 1DEB 1EMU 1JPP 1M5I 1T08 1TH1 1V18 2RQU 3AU3 3NMW 3NMX 3NMZ 3QHE 3RL7 3RL8 3T7U 4G69 4YJE 4YJL 4YK6 5B6G 5IZ6 5IZ8 5IZ9 5IZA 5Z8H
Enriched GO Terms of Interacting Partners?
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