NRDC and CALCA

Number of citations of the paper that reports this interaction (PubMedID 12590613)
3

Data Source:
HPRD (in vitro)

		NRDC	CALCA
Description		nardilysin convertase	calcitonin related polypeptide alpha
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Cytosol Cell Surface	Extracellular Region Extracellular Space Cell Nucleus Cytoplasm Neuronal Cell Body Terminal Bouton
	Molecular Function	Metalloendopeptidase Activity Protein Binding Metal Ion Binding Epidermal Growth Factor Binding	Hormone Activity Protein Binding Calcitonin Receptor Binding Identical Protein Binding
	Biological Process	Peptide Catabolic Process Positive Regulation Of Membrane Protein Ectodomain Proteolysis Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Endopeptidase Activity Negative Regulation Of Cold-induced Thermogenesis	Artery Vasodilation Involved In Baroreceptor Response To Increased Systemic Arterial Blood Pressure Monocyte Chemotaxis Inflammatory Response G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Neuropeptide Signaling Pathway Embryo Implantation Aging Feeding Behavior Regulation Of Heart Contraction Response To Heat Negative Regulation Of Ossification Activation Of Protein Kinase Activity Cellular Protein Metabolic Process Negative Regulation Of Bone Resorption Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Smooth Muscle Contraction Response To Pain Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G Protein-coupled Signaling Pathway Cellular Response To Tumor Necrosis Factor Cellular Response To Nerve Growth Factor Stimulus
Pathways			G alpha (s) signalling events Calcitonin-like ligand receptors ADORA2B mediated anti-inflammatory cytokines production Amyloid fiber formation G alpha (s) signalling events Calcitonin-like ligand receptors ADORA2B mediated anti-inflammatory cytokines production
Drugs			Olcegepant Telcagepant
Diseases
GWAS			Diverticular disease ( 30177863) Vitamin D levels ( 25208829)
Interacting Genes		6 interacting genes: CALCA H3C14 HBEGF NLGN3 PDYN POMC	7 interacting genes: BBS1 BBS4 CALCRL ECE1 NRDC RAMP1 RAMP2
Entrez ID		4898	796
HPRD ID		04036	00238
Ensembl ID		ENSG00000078618	ENSG00000110680
Uniprot IDs		G3V1R5 O43847 Q6UUU9	P01258 P06881
PDB IDs			1LS7 2JXZ 6E3Y
Enriched GO Terms of Interacting Partners?
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