NPPA and MAGEA12

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		NPPA	MAGEA12
Description		natriuretic peptide A	MAGE family member A12
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytoplasm Brush Border Protein-containing Complex Mast Cell Granule Perinuclear Region Of Cytoplasm Collagen-containing Extracellular Matrix	Cellular_component
	Molecular Function	Signaling Receptor Binding Hormone Activity Neuropeptide Hormone Activity Protein Binding Hormone Receptor Binding Neuropeptide Receptor Binding	Molecular_function Protein Binding
	Biological Process	Response To Hypoxia Negative Regulation Of Systemic Arterial Blood Pressure CGMP Biosynthetic Process Transcription Initiation From RNA Polymerase II Promoter Protein Folding Receptor Guanylyl Cyclase Signaling Pathway Neuropeptide Signaling Pathway Female Pregnancy Regulation Of Blood Pressure Positive Regulation Of Heart Rate Positive Regulation Of CGMP-mediated Signaling Cardiac Muscle Hypertrophy In Response To Stress CGMP-mediated Signaling Negative Regulation Of Cell Growth Response To Insulin Response To Muscle Stretch Negative Regulation Of JUN Kinase Activity Cellular Protein Metabolic Process Regulation Of Atrial Cardiac Muscle Cell Membrane Repolarization Positive Regulation Of Cardiac Muscle Contraction Cell Growth Involved In Cardiac Muscle Cell Development Cellular Response To Mechanical Stimulus Regulation Of High Voltage-gated Calcium Channel Activity Positive Regulation Of Delayed Rectifier Potassium Channel Activity Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Positive Regulation Of Histamine Secretion By Mast Cell Positive Regulation Of Potassium Ion Export Across Plasma Membrane Regulation Of Cardiac Conduction Negative Regulation Of Collecting Lymphatic Vessel Constriction	Biological_process
Pathways		YAP1- and WWTR1 (TAZ)-stimulated gene expression Physiological factors Amyloid fiber formation
Drugs
Diseases		Atrial fibrillation
GWAS		Atrial fibrillation ( 19597492) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Midregional pro atrial natriuretic peptide levels ( 29237677) Psoriasis ( 25854761) Pulse pressure ( 30578418) Systolic blood pressure ( 19430483 30578418) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Tuberculosis ( 29036319)
Interacting Genes		12 interacting genes: EPB41 ESR1 HNF4A MAGEA12 MME NPR1 NPR2 NPR3 NR5A2 RORB UBQLN1 UBQLN4	18 interacting genes: ABI3 C16orf87 CLIP4 FASTKD3 FNDC11 HK2 KANSL1 KHDC4 MTFR1L MTFR2 NANOS2 NPPA POLL SCMH1 STAT5A TBC1D19 UBE3A ZNF33B
Entrez ID		4878	4111
HPRD ID		00164	02169
Ensembl ID		ENSG00000175206	ENSG00000213401
Uniprot IDs		P01160	P43365
PDB IDs		1ANP 1YK0 3N57
Enriched GO Terms of Interacting Partners?
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