NPM1 and ACY1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		NPM1	ACY1
Description		nucleophosmin 1	aminoacylase 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Centrosome Cytosol Focal Adhesion Membrane Spindle Pole Centrosome Protein-containing Complex Protein-DNA Complex Ribonucleoprotein Complex	Cytosol Extracellular Exosome
	Molecular Function	Core Promoter Binding Chromatin Binding Transcription Coactivator Activity RNA Binding Protein Kinase Inhibitor Activity Protein Binding Transcription Factor Binding Protein Kinase Binding Tat Protein Binding Activating Transcription Factor Binding Histone Binding Protein Homodimerization Activity Ribosomal Large Subunit Binding Ribosomal Small Subunit Binding NF-kappaB Binding Unfolded Protein Binding	Aminoacylase Activity Protein Binding Metallopeptidase Activity Identical Protein Binding Metal Ion Binding
	Biological Process	Ribosomal Large Subunit Export From Nucleus Ribosomal Small Subunit Export From Nucleus DNA Repair Nucleosome Assembly Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II RRNA Export From Nucleus Intracellular Protein Transport Nucleocytoplasmic Transport Centrosome Cycle Signal Transduction Cell Aging Protein Localization Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Regulation Of Centrosome Duplication Negative Regulation Of Centrosome Duplication Viral Process Regulation Of Endodeoxyribonuclease Activity CENP-A Containing Nucleosome Assembly Cellular Response To UV Ribosome Assembly Ribosomal Large Subunit Biogenesis Ribosomal Small Subunit Biogenesis Negative Regulation Of Apoptotic Process Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation Positive Regulation Of Translation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Centriole Replication Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Endoribonuclease Activity Regulation Of EIF2 Alpha Phosphorylation By DsRNA Regulation Of MRNA Stability Involved In Cellular Response To UV Positive Regulation Of Cell Cycle G2/M Phase Transition	Proteolysis Cellular Amino Acid Metabolic Process Xenobiotic Metabolic Process
Pathways		Nuclear import of Rev protein Nuclear import of Rev protein SUMOylation of transcription cofactors Deposition of new CENPA-containing nucleosomes at the centromere TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	Aflatoxin activation and detoxification Defective ACY1 causes encephalopathy
Drugs		Artenimol	L-Aspartic Acid Acetylcysteine Copper
Diseases
GWAS		Height ( 28552196)
Interacting Genes		59 interacting genes: ABCC1 ACY1 ALK APP ARF1 CD24 CDK1 CDK2 CDKN2A CDT1 CENPW CLK1 COX8A CSNK2A1 EIF2AK2 ELF4 EP300 ERG ESR1 FBXW7 GADD45A GNAI2 GNL3 GRB2 GZMM H2AC20 H2BC21 H3-4 HAND2 HMGA1 HMGA2 HOXA7 IRF1 IRS1 MDM2 NCL NOP2 NPM2 PADI4 PARP1 PLCG1 PLCG2 PLK1 PSMC4 RELA RPGR SENP3 SHC1 SIL1 SP1 SREK1 TCERG1 TFAP2A TP53 TRIM28 UBC UQCRH XPO1 YY1	5 interacting genes: APP NPM1 POT1 TERF1 TTC1
Entrez ID		4869	95
HPRD ID		01246	00092
Ensembl ID		ENSG00000181163	ENSG00000243989
Uniprot IDs		A0A0S2Z491 A0A0S2Z4G7 A0A140VJQ2 P06748	Q03154 V9HWA0
PDB IDs		2LLH 2P1B 2VXD 5EHD	1Q7L
Enriched GO Terms of Interacting Partners?
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